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Aortic Valve Implantation: Recent Advances and Future Prospects

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 592

Special Issue Editors


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Guest Editor
Wessex Cardiothoracic Centre, University Hospital Southampton, Southampton SO16 6YD, UK
Interests: aortic valve replacement; aortic stenosis; paravalvular leak

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Guest Editor
Wessex Cardiothoracic Centre, University Hospital Southampton, Southampton SO16 6YD, UK
Interests: coronary and structural interventional cardiology; percutaneous coronary artery interventions; aortic valve implantation

Special Issue Information

Dear Colleagues,

Aortic disease is the most common valvular heart disease. Aortic valve implantation has become a therapy for patients with low- and intermediate-risk severe aortic stenosis. The wide range of diseases that can be treated using aortic valve implantation include insufficiency, subvalvular stenosis, endocarditis, and bicuspid degeneration.

Aortic valve diseases have experienced a revolution in the past decade with the introduction of valve implantation therapies providing a mini-invasive, safe, and efficient treatment for the majority of patients. Due to the increasing rate of valve implantation use, data on outcomes and variables impacting outcomes continue to be of interest. Recently research has focused on permanent pacemaker implantation rates, cases where the valve has become narrowed (aortic stenosis) or the valve is leaky (aortic regurgitation), aortic valve-in-valve procedures, and a new generation of trans-catheter heart valve devices.

This Special Issue aims to collect original articles, reviews, and other contributions on the current state and future developments of aortic valve implantation, focused on these and other related topics, aiming at bringing the reader up to date with the advances in aortic valve implantation.

Dr. Suvitesh Luthra
Dr. Richard Jabbour
Guest Editors

Manuscript Submission Information

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Keywords

  • aortic valve replacement
  • aortic stenosis
  • paravalvular leak
  • coronary and structural interventional cardiology
  • percutaneous coronary artery interventions

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Published Papers (1 paper)

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Review

26 pages, 2260 KiB  
Review
Transcatheter Aortic Valve Implantation in Cardiogenic Shock: Current Evidence, Clinical Challenges, and Future Directions
by Grigoris V. Karamasis, Christos Kourek, Dimitrios Alexopoulos and John Parissis
J. Clin. Med. 2025, 14(15), 5398; https://doi.org/10.3390/jcm14155398 (registering DOI) - 31 Jul 2025
Abstract
Cardiogenic shock (CS) in the setting of severe aortic stenosis (AS) presents a critical and high-risk scenario with limited therapeutic options and poor prognosis. Transcatheter aortic valve implantation (TAVI), initially reserved for inoperable or high-risk surgical candidates, is increasingly being considered in patients [...] Read more.
Cardiogenic shock (CS) in the setting of severe aortic stenosis (AS) presents a critical and high-risk scenario with limited therapeutic options and poor prognosis. Transcatheter aortic valve implantation (TAVI), initially reserved for inoperable or high-risk surgical candidates, is increasingly being considered in patients with CS due to improvements in device technology, operator experience, and supportive care. This review synthesizes current evidence from large registries, observational studies, and meta-analyses that support the feasibility, safety, and potential survival benefit of urgent or emergent TAVI in selected CS patients. Procedural success is high, and early intervention appears to confer improved short-term and mid-term outcomes compared to balloon aortic valvuloplasty or medical therapy alone. Critical factors influencing prognosis include lactate levels, left ventricular ejection fraction, renal function, and timing of intervention. The absence of formal guidelines, logistical constraints, and ethical concerns complicate decision-making in this unstable population. A multidisciplinary Heart Team/Shock Team approach is essential to identify appropriate candidates, manage procedural risk, and guide post-intervention care. Further studies and the development of TAVI-specific risk models in CS are anticipated to refine patient selection and therapeutic strategies. TAVI may represent a transformative option for stabilizing hemodynamics and improving outcomes in this otherwise high-mortality group. Full article
(This article belongs to the Special Issue Aortic Valve Implantation: Recent Advances and Future Prospects)
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