Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
Novelties in the Treatment of Glomerulonephritis
share announcement

Novelties in the Treatment of Glomerulonephritis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 2142

Special Issue Editor

Prof. Dr. Francesco Locatelli

E-Mail Website
Guest Editor
Former Director, Department of Nephrology and Dialysis, Alessandro Manzoni Hospital, 23900 Lecco, Italy
Interests: CKD; proteinuria; hypertension; anemia; ESAS; iron; dialysis; glomerulonephritis; electrolytes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As you well know, primary and secondary glomerulonephritis are related to systemic autoimmune diseases, infections, drugs, or neoplasia and affect a significant percentage of patients of all ages, including children and young adults, where it is the most common cause of end-stage kidney disease. In the past, the therapeutic approach was mostly based on steroids, including boli, eventually alternated each month with alkilants for 6 months or on cyclosporine, depending on the type of glomerulonephritis. Over the last few years, several advancements have been made on the pathogenesis, diagnosis, and treatment of these diseases. In this regard, important steps were made, including the demonstration that primary membranous nephropathy is an autoimmune disease and the increasing recognition of the important pathogenetic role of the complement and of the B cells, leading to the development and use of drugs aiming at this target. It is our pleasure to invite you to contribute to this Special Issue.

Prof. Dr. Francesco Locatelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glomerulonephritis
  • primary and secondary
  • IGA nephritis
  • membranous nephropathy
  • minimal change nephropathy
  • glomerulosclerosis
  • C3 glomerulonephritis
  • vasculitis systemic steroids
  • budesonide
  • alkilants
  • cyclosporine
  • complement
  • rituximab
  • SGLT2
  • sparsentan

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

17 pages, 1325 KiB  
Review
The Recurrence of Systemic Diseases in Kidney Transplantation
by Gabriella Moroni, Marta Calatroni and Claudio Ponticelli
J. Clin. Med. 2025, 14(8), 2592; https://doi.org/10.3390/jcm14082592 - 9 Apr 2025
Viewed by 519
Abstract
Kidney transplantation is the most effective replacement therapy for kidney failure, providing the best outcomes in terms of patient survival and offering a better quality of life. However, despite the progressive improvement in kidney survival, the recurrence of original disease remains one of [...] Read more.
Kidney transplantation is the most effective replacement therapy for kidney failure, providing the best outcomes in terms of patient survival and offering a better quality of life. However, despite the progressive improvement in kidney survival, the recurrence of original disease remains one of the most important causes of graft loss and a major challenge that requires clinical vigilance throughout the transplant’s duration. Additionally, the type and severity of recurrence affect both treatment options and graft survival. This is especially true for the recurrence of systemic diseases. In this narrative review, we will discuss the timing, frequency, severity, and treatment of post-transplant recurrence in three systemic diseases: lupus nephritis (LN), Antineutrophil Cytoplasmic Antibodies (ANCA)-associated glomerulonephritis (ANCA-GN), and Henoch–Schönlein purpura (HSP). The recurrence of lupus nephritis is less common than that of primary focal segmental glomerulosclerosis or C3 glomerulopathy. Its severity can range from mild mesangial to diffuse proliferative forms, with varying prognoses and treatment options, much like the original disease. In some patients with LN, as well as in those with ANCA-GN or HSP, the reactivation of the primary disease can affect other organs besides the kidneys, potentially leading to life-threatening conditions. These cases may require a multidisciplinary approach, making these transplants clinically more challenging. Extrarenal flare-ups often necessitate an increase in immunosuppression, which in turn raises the risk of infections. In these autoimmune diseases, the role of immunological tests in determining the timing of kidney transplants remains a topic of ongoing debate. However, elevated levels of certain immunological markers, such as anti-dsDNA antibodies, ANCA titers, or serum immunoglobulin A may indicate a reactivation of the disease, suggesting the need for more intensive patient monitoring. Full article
(This article belongs to the Special Issue Novelties in the Treatment of Glomerulonephritis)
►▼ Show Figures

Figure 1

19 pages, 905 KiB  
Review
Membranous Nephropathy
by Claudio Ponticelli
J. Clin. Med. 2025, 14(3), 761; https://doi.org/10.3390/jcm14030761 - 24 Jan 2025
Viewed by 1207
Abstract
Membranous nephropathy is a glomerular disease that may be caused by exogenous risk factors in genetically predisposed individuals (primary MN) or may be associated with other autoimmune diseases, drug exposure, or cytotoxic agents (secondary MN). Primary membranous nephropathy (PMN) is an autoimmune disease [...] Read more.
Membranous nephropathy is a glomerular disease that may be caused by exogenous risk factors in genetically predisposed individuals (primary MN) or may be associated with other autoimmune diseases, drug exposure, or cytotoxic agents (secondary MN). Primary membranous nephropathy (PMN) is an autoimmune disease in which antigens—mainly the phospholipase A2 receptor—are located in the podocytes and are targeted by circulating antibodies, leading to in situ formation of immune complexes that activate the complement system. Clinically, the disease is characterized by nephrotic syndrome (NS) and associated complications. The outcome of PMN can vary, but untreated patients with NS may progress to end-stage kidney disease (ESKD) in 35–40% of cases within 10 years. Treatment primarily aims to prevent NS complications and progression to ESKD. The most commonly used immunosuppressive drugs are rituximab, corticosteroids, cyclophosphamide, and calcineurin inhibitors. Most patients may experience an improvement of proteinuria, which can sometimes be followed by NS relapse. Fewer than 50% of patients with PMN achieve complete and stable remission. In addition to immunosuppressive therapy, antiproteinuric, anti-lipemic, and anticoagulant medicaments are often required. Full article
(This article belongs to the Special Issue Novelties in the Treatment of Glomerulonephritis)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop