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Diagnosis and Management Strategies for Dry Eye Disease
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Diagnosis and Management Strategies for Dry Eye Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 3508

Special Issue Editor

Dr. Antonio Di Zazzo

E-Mail Website
Guest Editor
Ophthalmology Complex Unit, Campus Bio-Medico University Hospital, Rome, Italy
Interests: cornea; corneal transplantation; dry eye disease; allergy; corneal angiogenesis; immunology; refractive surgery; stem cell transplantation; keratoprosthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In July 2020, the first volume of the Special Issue “Pathogenesis of the Homeostatic Failure of Ocular Surface as Morpho-Functional Unit” was launched (https://www.mdpi.com/journal/jcm/special_issues/ocular_surface). We received many excellent papers on the topic of the ocular surface and its diseases. Now, we would like to launch the new volume on this topic, focusing on evaporative alterations in tears.

The ocular surface system interacts with, reacts with, and adapts to daily continuous insults, trauma, and stimuli caused by direct exposure to the atmosphere and environment. Several tissue and para-inflammatory mechanisms interact to guarantee such functions, maintaining a healthy homeostatic equilibrium. Evaporation seriously affects this homeostasis, thereby becoming a critical trigger in the pathogenesis of the vicious cycle of dry eye disease (DED). Tear film lipid composition, distribution, spreading, and efficiency are crucial factors in controlling water evaporation, and are involved in the onset of the hyperosmolar and inflammatory cascades of DED. The structure of tear film lipids, and subsequently the tear film, has a considerable impact on the properties and main functions of tears, leading to a peculiar clinical picture and specific management.

The main aim of this Special Issue is to investigate the evaporative changes in dry eye disease, which affect 80% of patients. It will focus on their causes, biochemical changes, diagnostic methods, and innovative treatments.

Dr. Antonio Di Zazzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dry eye disease
  • ocular surface diseases
  • ocular surface diabetic disease

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Published Papers (2 papers)

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12 pages, 1599 KiB  
Article
Comparative Analysis of Intense Pulsed Light Therapy in Patients with Meibomian Gland Dysfunction, with and Without Glaucoma Medication
by Kwang-Eon Han, Jinho Kim, Su-Jin Kim, Jonghoon Shin, Eun-Jung Choi, Sangmin Kim, Dogyu Lee, Jeongyun Kim, Sangwoo Moon and Ji-Eun Lee
J. Clin. Med. 2024, 13(21), 6341; https://doi.org/10.3390/jcm13216341 - 23 Oct 2024
Viewed by 1194
Abstract
Background: This study assessed the efficacy of intense pulsed light (IPL) therapy for treating meibomian gland dysfunction (MGD), a key contributor to evaporative dry eye disease (DED), by comparing outcomes in patients with idiopathic MGD versus those with MGD induced by glaucoma [...] Read more.
Background: This study assessed the efficacy of intense pulsed light (IPL) therapy for treating meibomian gland dysfunction (MGD), a key contributor to evaporative dry eye disease (DED), by comparing outcomes in patients with idiopathic MGD versus those with MGD induced by glaucoma medications. Methods: In a retrospective analysis of 45 patients, divided into groups based on glaucoma medication use (20 patients) and non-use (25 patients), all underwent four IPL sessions combined with meibomian gland expression (MGX) at 3-week intervals. Key metrics evaluated included Ocular Surface Disease Index (OSDI) scores, tear breakup time (TBUT), Schirmer I test scores, and meibography scores, pre- and post-treatment. Results: Significant improvements were observed in both groups across all parameters post-treatment, indicating enhanced tear film stability and meibomian gland function. The non-glaucoma group showed slightly greater improvements, suggesting the potential impact of glaucoma medications on MGD management. Conclusions: These findings underscore IPL therapy’s effectiveness in improving DED symptoms and meibomian gland function, highlighting its utility as a treatment option for patients with MGD, including those on glaucoma medications. Full article
(This article belongs to the Special Issue Diagnosis and Management Strategies for Dry Eye Disease)
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9 pages, 1397 KiB  
Case Report
Customized Scleral Lenses: An Alternative Tool for Severe Dry Eye Disease—A Case Series
by Sebastiano Nunziata, Daniele Petrini, Serena Dell’Anno, Vincenzo Barone, Marco Coassin and Antonio Di Zazzo
J. Clin. Med. 2024, 13(13), 3935; https://doi.org/10.3390/jcm13133935 - 4 Jul 2024
Cited by 2 | Viewed by 1799
Abstract
Purpose: Dry eye disease (DED) is a multifactorial condition significantly impacting patients’ quality of life (QoL). This study aims to present a case series highlighting the effectiveness of customized scleral lenses in managing severe DED and improving patient outcomes. Methods: This case series [...] Read more.
Purpose: Dry eye disease (DED) is a multifactorial condition significantly impacting patients’ quality of life (QoL). This study aims to present a case series highlighting the effectiveness of customized scleral lenses in managing severe DED and improving patient outcomes. Methods: This case series includes three patients with severe DED refractory to conventional treatments. Customized scleral lenses were fitted for each patient, and clinical outcomes were evaluated over a period of two months. Assessments included best-corrected visual acuity (BCVA), slit-lamp examination findings, and corneal National Eye Institute (NEI) scores. Results: All three patients demonstrated significant improvements in BCVA, reductions in ocular symptoms, and enhanced ocular surface health. Patient 1, with secondary Sjögren’s syndrome and suspected mucous membrane pemphigoid, showed resolution of conjunctival hyperemia and epithelial defects. Patient 2, with graft versus host disease, exhibited resolution of punctate keratitis and the absence of thread mucus. Patient 3, post-oncologic surgery, achieved complete resolution of keratoconjunctivitis sicca and the restoration of vision. Conclusions: Customized scleral lenses are a useful therapeutic option for severe DED, providing significant symptomatic relief and enhancing patients’ quality of life. Their use should be considered in refractory cases to optimize ocular surface health and visual outcomes. Full article
(This article belongs to the Special Issue Diagnosis and Management Strategies for Dry Eye Disease)
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