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7 July 2025
Journal of Clinical Medicine | Highly Cited Papers and Hot Topic Special Issues on Liver Diseases


Chronic liver disease is a major global health challenge and has long posed a serious threat to the quality of human life. We sincerely recommend the highly cited papers on liver diseases selected in the Journal of Clinical Medicine (JCM, ISSN: 2077-0383) in the past two years. Each of them is the result of the hard work and wisdom of elite scientific researchers. These selected papers cover multiple dimensions, such as liver transplantation technology innovation, liver fibrosis, and nonalcoholic fatty liver disease. Medical practitioners and enthusiasts are welcome to read for free. At the same time, the channel for soliciting papers on liver diseases in JCM has been opened. We recommend four hot Special Issues for you, and we look forward to your cutting-edge research and innovative results. For more research on liver diseases, please check: https://www.mdpi.com/search?advanced=(@(title)liver.

1. “Introducing Machine Perfusion into Routine Clinical Practice for Liver Transplantation in the United States: The Moment Has Finally Come
Kristopher P. Croome
J. Clin. Med. 2023, 12(3), 909; https://doi.org/10.3390/jcm12030909
Full text available online: https://www.mdpi.com/2077-0383/12/3/909

2. “Metabolic Disorders in Liver Transplant Recipients: The State of the Art
by Filippo Gabrielli, Lucia Golfieri, Fabio Nascimbeni, Pietro Andreone and Stefano Gitto
J. Clin. Med. 2024, 13(4), 1014; https://doi.org/10.3390/jcm13041014
Full text available online: https://www.mdpi.com/2077-0383/13/4/1014

3. “The Interplay between Liver Sinusoidal Endothelial Cells, Platelets, and Neutrophil Extracellular Traps in the Development and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease
by Iulia Minciuna, Madalina Gabriela Taru, Bogdan Procopet and Horia Stefanescu
J. Clin. Med. 2024, 13(5), 1406; https://doi.org/10.3390/jcm13051406
Full text available online: https://www.mdpi.com/2077-0383/13/5/1406

4. “Efficacy and Safety of a Probiotic Containing Saccharomyces boulardii CNCM I-745 in the Treatment of Small Intestinal Bacterial Overgrowth in Decompensated Cirrhosis: Randomized, Placebo-Controlled Study
by Irina Efremova, Roman Maslennikov, Maria Zharkova, Elena Poluektova, Nona Benuni, Aleksandr Kotusov, Tatyana Demina, Aleksandra Ivleva, Farida Adzhieva, Taisiya Krylova et al.
J. Clin. Med. 2024, 13(3), 919; https://doi.org/10.3390/jcm13030919
Full text available online: https://www.mdpi.com/2077-0383/13/3/919

5. “Non-Invasive Assessment of Liver Fibrosis in Hepatitis B Patients
by Chinmay Bera, Nashla Hamdan-Perez and Keyur Patel
J. Clin. Med. 2024, 13(4), 1046; https://doi.org/10.3390/jcm13041046
Full text available online: https://www.mdpi.com/2077-0383/13/4/1046

6. “Hepatitis B Virus Reactivation with Immunosuppression: A Hidden Threat?
by Sama Anvari and Keith Tsoi
J. Clin. Med. 2024, 13(2), 393; https://doi.org/10.3390/jcm13020393
Full text available online: https://www.mdpi.com/2077-0383/13/2/393

7. “Steatotic Liver Disease and Sepsis Outcomes—A Prospective Cohort Study (SepsisFAT)
by Juraj Krznaric, Neven Papic, Nina Vrsaljko, Branimir Gjurasin, Marko Kutlesa and Adriana Vince
J. Clin. Med. 2024, 13(3), 798; https://doi.org/10.3390/jcm13030798
Full text available online: https://www.mdpi.com/2077-0383/13/3/798

8. “Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease (NAFLD/MAFLD)
by Damian Dyńka, Łukasz Rodzeń, Mateusz Rodzeń, Dorota Łojko, Sebastian Kraszewski, Ali Ibrahim, Maria Hussey, Adam Deptuła, Żaneta Grzywacz, Alexandre Ternianov et al.
J. Clin. Med. 2024, 13(16), 4857; https://doi.org/10.3390/jcm13164857
Full text available online: https://www.mdpi.com/2077-0383/13/16/4857

9. “Hepatitis C Virus (HCV) Infection: Pathogenesis, Oral Manifestations, and the Role of Direct-Acting Antiviral Therapy: A Narrative Review
by Dario Di Stasio, Agostino Guida, Antonio Romano, Massimo Petruzzi, Aldo Marrone, Fausto Fiori and Alberta Lucchese
J. Clin. Med. 2024, 13(14), 4012; https://doi.org/10.3390/jcm13144012
Full text available online: https://www.mdpi.com/2077-0383/13/14/4012

10. “The Prognostic Value of a Liver Function Test Using Indocyanine Green (ICG) Clearance in Patients with Multiple Organ Dysfunction Syndrome (MODS)
by Franz Haertel, Sebastian Nuding, Diana Reisberg, Martin Peters, Karl Werdan, P. Christian Schulze and Henning Ebelt
J. Clin. Med. 2024, 13(4), 1039; https://doi.org/10.3390/jcm13041039
Full text available online: https://www.mdpi.com/2077-0383/13/4/1039

Special Issues

Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
Guest Editor: Dr. Hirsh D. Trivedi
Submission deadline: 20 December 2025

Advances in Hepatitis: Prevention, Treatment, and Global Health Impact
Guest Editors: Dr. Michał Brzdęk, Prof. Dr. Dorota Zarębska-Michaluk and Dr. Krystyna Dobrowolska
Submission deadline: 28 January 2026

Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation
Guest Editor: Dr. Adriano Pellicelli
Submission deadline: 20 February 2026

Current and Emerging Treatment Options in Chronic Liver Diseases
Guest Editor: Dr. Chandana B. Herath
Submission deadline: 28 February 2026

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