Myocardial Proliferation in Development and Regeneration
A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).
Deadline for manuscript submissions: closed (30 November 2018) | Viewed by 344
Special Issue Editor
Interests: cardiac progenitor cell; cardiac development; transcriptional regulation; Nkx2-5; myocardial regeneration; induced pluripotent stem cell
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of JCDD is focused on the topic of “Myocardial Prolifearation in Development and Regeneration”, which we believe to be of significant interest to many cardiac developmental biologists, stem cell biologists, and clinician scientists seeking to employ regenerative approaches to cardiovascular diseases. Recent advances in myocardial proliferation during embryogenesis and after neonatal cardiac injury has our improved understanding of the key regulatory events driving cardiac development and differentiation. They have also opened numerous areas of investigation from cell cycling in fetal cardiomyocytes to dedifferentiation of adult cardiomyocytes for regenerative applications. These exciting research pursuits have also raised important questions regarding the risks vs. benefits of inducing cardiomyocyte division in fully mature adult cardiomyocytes and the challenges that must be overcome to effectively deliver therapeutic agents to achieve improvement in overall cardiac function and long-term patient survival. In this rapidly evolving research field, we hope to illustrate the promises and the pitfalls of cardiomyocyte proliferation for normal development, and highlight key opportunities where this approach may lead to promising new therapies for cardiac regeneration.
Prof. Dr. Sean M. WuGuest Editor
Manuscript Submission Information
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Keywords
- Atrial and ventricular cardiomyocyte
- Cardiomyocyte dedifferentiation
- Cardiomyocyte proliferation
- Myocardial development
- Myocardial regeneration
- Pluripotent stem cells
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