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Cardiovascular Imaging in Heart Failure and in Valvular Heart Disease
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Cardiovascular Imaging in Heart Failure and in Valvular Heart Disease

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Imaging".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 900

Special Issue Editors

Dr. Daniel A. Morris

E-Mail Website
Guest Editor
Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 13353 Berlin, Germany
Interests: heart failure; diastolic dysfunction; echocardiography; strain imaging; valvular heart disease; left atrial function
Special Issues, Collections and Topics in MDPI journals
Dr. Evgeny Belyavskiy

E-Mail Website
Guest Editor
Deutsches Herzzentrum der Charité, Medizinisches Versorgungszentrum, Augustenburger Platz 1, 13353 Berlin, Germany
Interests: HFpEF (heart failure with preserved ejection fraction); diastolic dysfunction; echocardiography; stress-echocardiography; diastolic stress test; speckle-tracking echocardiography; strain; hypertension; sleep apnea
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

At present, the Journal of Cardiovascular Development and Disease is planning a Special Issue entitled "Cardiovascular Imaging in Heart Failure and in Valvular Heart Disease". This will highlight the potential usefulness and clinical relevance of cardiovascular imaging techniques such as echocardiography, cardiovascular magnetic resonance, and cardiac computed tomography in patients with heart failure and in patients with valvular heart disease. Specifically, this issue will address the clinical, prognostic, or diagnostic relevance of new imaging parameters or new proposed diagnostic indices or algorithms in patients with heart failure and in patients with valvular heart disease.

We are looking forward to receiving your contributions. These may be submitted as an original research article, a review article, a meta-analysis article, a systematic-review article, a clinical trial, or a study design article.

Dr. Daniel A. Morris
Dr. Evgeny Belyavskiy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • valvular heart disease
  • aortic valve stenosis
  • mitral valve regurgitation
  • tricuspid valve regurgitation
  • aortic valve regurgitation
  • echocardiography
  • cardiovascular magnetic resonance
  • cardiac computed tomography

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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18 pages, 4979 KiB  
Systematic Review
Discordant High-Gradient Aortic Stenosis: A Systematic Review
by Nadera N. Bismee, Mohammed Tiseer Abbas, Hesham Sheashaa, Fatmaelzahraa E. Abdelfattah, Juan M. Farina, Kamal Awad, Isabel G. Scalia, Milagros Pereyra Pietri, Nima Baba Ali, Sogol Attaripour Esfahani, Omar H. Ibrahim, Steven J. Lester, Said Alsidawi, Chadi Ayoub and Reza Arsanjani
J. Cardiovasc. Dev. Dis. 2025, 12(7), 255; https://doi.org/10.3390/jcdd12070255 - 3 Jul 2025
Viewed by 324
Abstract
Aortic stenosis (AS), the most common valvular heart disease, is traditionally graded based on several echocardiographic quantitative parameters, such as aortic valve area (AVA), mean pressure gradient (MPG), and peak jet velocity (Vmax). This systematic review evaluates the clinical significance and prognostic implications [...] Read more.
Aortic stenosis (AS), the most common valvular heart disease, is traditionally graded based on several echocardiographic quantitative parameters, such as aortic valve area (AVA), mean pressure gradient (MPG), and peak jet velocity (Vmax). This systematic review evaluates the clinical significance and prognostic implications of discordant high-gradient AS (DHG-AS), a distinct hemodynamic phenotype characterized by elevated MPG despite a preserved AVA (>1.0 cm2). Although often overlooked, DHG-AS presents unique diagnostic and therapeutic challenges, as high gradients remain a strong predictor of adverse outcomes despite moderately reduced AVA. Sixty-three studies were included following rigorous selection and quality assessment of the key studies. Prognostic outcomes across five key studies were discrepant: some showed better survival in DHG-AS compared to concordant high-gradient AS (CHG-AS), while others reported similar or worse outcomes. For instance, a retrospective observational study including 3209 patients with AS found higher mortality in CHG-AS (unadjusted HR: 1.4; 95% CI: 1.1 to 1.7), whereas another retrospective multicenter study including 2724 patients with AS observed worse outcomes in DHG-AS (adjusted HR: 1.59; 95% CI: 1.04 to 2.56). These discrepancies may stem from delays in intervention or heterogeneity in study populations. Despite the diagnostic ambiguity, the presence of high gradients warrants careful evaluation, aggressive risk stratification, and timely management. Current guidelines recommend a multimodal approach combining echocardiography, computed tomography (CT) calcium scoring, transesophageal echocardiography (TEE) planimetry, and, when needed, catheterization. Anatomic AVA assessment by TEE, CT, and cardiac magnetic resonance imaging (CMR) can improve diagnostic accuracy by directly visualizing valve morphology and planimetry-based AVA, helping to clarify the true severity in discordant cases. However, these modalities are limited by factors such as image quality (especially with TEE), radiation exposure and contrast use (in CT), and availability or contraindications (in CMR). Management remains largely based on CHG-AS protocols, with intervention primarily guided by transvalvular gradient and symptom burden. The variability among the different guidelines in defining severity and therapeutic thresholds highlights the need for tailored approaches in DHG-AS. DHG-AS is clinically relevant and associated with substantial prognostic uncertainty. Timely recognition and individualized treatment could improve outcomes in this complex subgroup. Full article
(This article belongs to the Special Issue Cardiovascular Imaging in Heart Failure and in Valvular Heart Disease)
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