Advances in Diagnosis and Interventional Therapy of Coronary Artery Disease

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Acquired Cardiovascular Disease".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 286

Special Issue Editors


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Guest Editor
U.O.S. Emodinamica, U.O.C. Cardiologia, Ospedale San Antonio Abate, 91016 Erice, Italy
Interests: interventional cardiology; intravascular ultrasound (IVUS); coronary imaging; optical coherence tomography (OCT); percutaneous coronary intervention (PCI); bioresorbable scaffold (BRS); drug-coated balloon (DCB)
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
U.O.S. Emodinamica, U.O.C. Cardiologia, Ospedale San Antonio Abate, 91016 Erice, Italy
Interests: percutaneous coronary intervention (PCI); optical coherence tomography (OCT); coronary bifurcation PCI technique; T and small protrusion (TAP) PCI; severe aortic stenosis; transcatheter aortic valve implantation (TAVI)

Special Issue Information

Dear Colleagues,

Coronary artery disease is the leading cause of death worldwide. Intracoronary imaging and coronary physiology techniques allow for a tailored diagnosis (distinguishing between fixed coronary stenosis, vasospasm, microcirculatory dysfunction, coronary dissection, and plaque rupture and erosion). Furthermore, percutaneous coronary intervention (PCI), the most widely used myocardial revascularization technique, has undergone numerous advances thanks to the introduction of intracoronary imaging, drug-coated balloons, and bioresorbable scaffolds (BRSs). Moreover, coronary bifurcations represent a challenge for the interventional cardiologist and are associated with a higher failure rate.

This topic will cover the following important aspects of coronary artery disease diagnosis and treatment:

  • Treatment of coronary bifurcation lesions;
  • Intracoronary imaging (intravascular ultrasound (IVUS); optical coherence tomography (OCT));
  • Coronary physiology techniques;
  • Drug-coated balloons;
  • Bioresorbable scaffold (BRS).

Research articles, review articles, and communications are invited.

Dr. Dario Buccheri
Guest Editor

Dr. Stefano Cangemi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • percutaneous coronary intervention (PCI)
  • coronary bifurcation techniques
  • intracoronary imaging (optical coherence tomography (OCT))
  • intravascular ultrasound (IVUS)
  • bioresorbable scaffold (BRS)
  • drug-coated balloon (DCB)
  • coronary physiology technique

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Published Papers (1 paper)

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Review

20 pages, 631 KiB  
Review
Trading off Iodine and Radiation Dose in Coronary Computed Tomography
by Guillaume Fahrni, Thomas Saliba, Damien Racine, Marianna Gulizia, Georgios Tzimas, Chiara Pozzessere and David C. Rotzinger
J. Cardiovasc. Dev. Dis. 2025, 12(5), 195; https://doi.org/10.3390/jcdd12050195 - 20 May 2025
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Abstract
Coronary CT angiography (CCTA) has seen steady progress since its inception, becoming a key player in the non-invasive assessment of coronary artery disease (CAD). Advancements in CT technology, including iterative and deep-learning-based reconstruction, wide-area detectors, and dual-source systems, have helped mitigate early limitations, [...] Read more.
Coronary CT angiography (CCTA) has seen steady progress since its inception, becoming a key player in the non-invasive assessment of coronary artery disease (CAD). Advancements in CT technology, including iterative and deep-learning-based reconstruction, wide-area detectors, and dual-source systems, have helped mitigate early limitations, such as high radiation doses, motion artifacts, high iodine load, and non-diagnostic image quality. However, the adjustments between ionizing radiation and iodinated contrast material (CM) volumes remain a critical concern, especially due to the increasing use of CCTA in various indications. This review explores the balance between radiation and CM volumes, emphasizing patient-specific protocol optimization to improve diagnostic accuracy while minimizing risks. Radiation dose reduction strategies, such as low tube voltage protocols, prospective ECG-gating, and modern reconstruction algorithms, have significantly decreased radiation exposure, with some studies achieving sub-millisievert doses. Similarly, CM volume optimization, including adjustments in strategies for calculating CM volume, iodine concentration, and flow protocols, plays a role in managing risks such as contrast-associated acute kidney injury, particularly in patients with renal impairment. Emerging technologies, such as photon-counting CT and deep-learning reconstruction, promise further improvements in dose efficiency and image quality. This review summarizes current evidence, highlights the benefits and limitations of dose control approaches, and provides practical recommendations for practitioners. By tailoring protocols to patient characteristics, such as age, renal function, and body habitus, clinicians can achieve an optimal trade-off between diagnostic accuracy and patient safety, ensuring optimal operation of CT systems in clinical practice. Full article
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