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Photocracking Silica: Tuning the Plasmonic Photothermal Degradation of Mesoporous Silica Encapsulating Gold Nanoparticles for Cargo Release

1
Chemical and Biological Engineering, University of New Mexico, 210 University Blvd NE, Albuquerque, NM 87131-0001, USA
2
Center for Micro-Engineered Materials, Advanced Materials Laboratory, University of New Mexico, MSC04 2790, 1001 University Blvd SE, Suite 103, Albuquerque, NM 87106, USA
3
Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Inorganics 2019, 7(6), 72; https://doi.org/10.3390/inorganics7060072
Received: 6 May 2019 / Revised: 31 May 2019 / Accepted: 31 May 2019 / Published: 6 June 2019
(This article belongs to the Special Issue Inorganic Nanoparticles in Cancer Therapy)
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Abstract

The degradation of bionanomaterials is essential for medical applications of nanoformulations, but most inorganic-based delivery agents do not biodegrade at controllable rates. In this contribution, we describe the controllable plasmonic photocracking of [email protected] nanoparticles by tuning the power and wavelength of the laser irradiation, or by tuning the size of the encapsulated gold cores. Particles were literally broken to pieces or dissolved from the inside out upon laser excitation of the plasmonic cores. The photothermal cracking of silica, probably analogous to thermal fracturing in glass, was then harnessed to release cargo molecules from [email protected]@polycaprolactone nanovectors. This unique and controllable plasmonic photodegradation has implications for nanomedicine, photopatterning, and sensing applications. View Full-Text
Keywords: degradation; plasmonic; gold nanoparticles; mesoporous silica nanoparticles; photothermal; polymer coating degradation; plasmonic; gold nanoparticles; mesoporous silica nanoparticles; photothermal; polymer coating
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Croissant, J.G.; Guardado-Alvarez, T.M. Photocracking Silica: Tuning the Plasmonic Photothermal Degradation of Mesoporous Silica Encapsulating Gold Nanoparticles for Cargo Release. Inorganics 2019, 7, 72.

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