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Open AccessArticle

Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin

1
BioSense Institute, University of Novi Sad, Dr Zorana Djindjica 1, 21000 Novi Sad, Serbia
2
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia
3
Oncology Institute of Vojvodina, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia
*
Author to whom correspondence should be addressed.
Inorganics 2019, 7(2), 16; https://doi.org/10.3390/inorganics7020016
Received: 15 January 2019 / Revised: 31 January 2019 / Accepted: 1 February 2019 / Published: 5 February 2019
(This article belongs to the Special Issue Inorganic Nanoparticles in Cancer Therapy)
Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m2/g). The material’s surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues. View Full-Text
Keywords: drug delivery; nanocarrier; porous nanoparticles; cancer treatment drug delivery; nanocarrier; porous nanoparticles; cancer treatment
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MDPI and ACS Style

Knežević, N.Ž.; Djordjević, S.; Kojić, V.; Janaćković, D. Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin. Inorganics 2019, 7, 16.

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