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State-of-the-Art Molecular Toxicology in Europe (Closed)

A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Molecular Toxicology".

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Editors


grade E-Mail Website
Collection Editor
Department of Chemistry, Faculty of Science, University of Hradec Králové, 50003 Hradec Králové, Czech Republic
Interests: toxins; drug design and development; antidotes for pesticide and nerve agent intoxications; Alzheimer’s disease; detergents as disinfectants, decontamination means; nanotechnology; health economics and pharmacoeconomics
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grade E-Mail Website
Collection Editor
Department of Physical Chemistry, Faculty of Chemical Technology, Slovak University of Technology, Bratislava, Slovakia
Interests: anticancer metal complexes; copper complexes; EPR spectroscopy; metals and oxidative stress; metal in health and disease

Topical Collection Information

Dear Colleagues,

This Topic Collection aims to rapidly publish contributions that describe the mechanism of toxicity of compounds in animals, humans, or appropriate in vitro models from European scholars. It is situated at the cutting edge of chemistry, biology and their relation to health. The focus is on the molecule and its interaction with biomolecules, as this interaction results in the actual biological effect. Molecular methods aimed at preventing toxicity or enhancing our understanding of health risk assessment are also of interest.

Topics include, but are not limited to:

  • Food, drug and chemical toxicology;
  • Genotoxicity;
  • Reproductive toxicology;
  • Neurotoxicology;
  • Clinical toxicology;
  • Nanotoxicology;
  • Environmental and ecotoxicology;
  • Computational and predictive toxicology;
  • Food-drug interactions;
  • Toxins;
  • Alternative toxicity testing.

Prof. Dr. Kamil Kuca
Dr. Eugenie Nepovimova
Prof. Dr. Marian Valko
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

2024

Jump to: 2022

19 pages, 4885 KiB  
Article
Effect of a New Substance with Pyridoindole Structure on Adult Neurogenesis, Shape of Neurons, and Behavioral Outcomes in a Chronic Mild Stress Model in Rats
by Alexandra Zvozilova, Alexandra Reichova, Mojmir Mach, Jan Bakos and Romana Koprdova
Int. J. Mol. Sci. 2024, 25(2), 845; https://doi.org/10.3390/ijms25020845 - 10 Jan 2024
Cited by 1 | Viewed by 1307
Abstract
Despite an accumulating number of studies, treatments for depression are currently insufficient. Therefore, the search for new substances with antidepressant potential is very important. In this study, we hypothesized that treatment with a newly synthesized pyridoindole derivative compound SMe1EC2M3 would result in protective [...] Read more.
Despite an accumulating number of studies, treatments for depression are currently insufficient. Therefore, the search for new substances with antidepressant potential is very important. In this study, we hypothesized that treatment with a newly synthesized pyridoindole derivative compound SMe1EC2M3 would result in protective and antidepressant-like effects on behavioral outcomes and reverse the impaired adult hippocampal neurogenesis caused by chronic mild stress (CMS). We found that chronic administration of 5 mg/kg and 25 mg/kg SMe1EC2M3 to adult Sprague Dawley rats ameliorated the consequences of CMS on immobility and swimming time in a forced swim test. A slight sedative effect of the highest dose of SMe1EC2M3 in the nonstress group was observed in the open field. SMe1EC2M3 in the highest dose ameliorated CMS-induced decreases in the sucrose preference test. Administration of SMe1EC2M3 significantly increased SOX2-positive cells in the hippocampal dentate gyrus (DG) in CMS compared to control animals. A significant reduction in glial fibrillary acid protein (GFAP)-positive cells in the DG of CMS compared to control animals was observed. Administration of both 5 and 25 mg/kg SMe1EC2M3 significantly increased signal of GFAP-positive cells in the DG of CMS animals. No such effects of SMe1EC2M3 were observed in the cornu ammonis hippocampal area. Additionally, we found that incubation of primary hippocampal neurons in the presence of 1.50 µM SMe1EC2M3 significantly stimulated the length of neurites. Overall, we found that the negative effects of CMS on depression-like behavior are partially reduced by the administration of SMe1EC2M3 and are associated with changes in hippocampal neurogenesis and neuronal differentiation. SMe1EC2M3 represents a potential drug candidate with positive neuroplastic effects and neurogenesis-associated effects in therapeutic approaches to depression. Full article
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Graphical abstract

2022

Jump to: 2024

16 pages, 1253 KiB  
Article
Microplastic-Induced Oxidative Stress in Metolachlor-Degrading Filamentous Fungus Trichoderma harzianum
by Anna Jasińska, Sylwia Różalska, Volha Rusetskaya, Mirosława Słaba and Przemysław Bernat
Int. J. Mol. Sci. 2022, 23(21), 12978; https://doi.org/10.3390/ijms232112978 - 26 Oct 2022
Cited by 17 | Viewed by 2458
Abstract
While there has been intensive research on the influence of microplastics (MPs) on aquatic organisms and humans, their effect on microorganisms is relatively little-known. The present study describes the response of the Trichoderma harzianum strain to low-density polyethylene (LDPE) microparticles. MPs, either separately [...] Read more.
While there has been intensive research on the influence of microplastics (MPs) on aquatic organisms and humans, their effect on microorganisms is relatively little-known. The present study describes the response of the Trichoderma harzianum strain to low-density polyethylene (LDPE) microparticles. MPs, either separately or with metolachlor (MET), were added to the cultures. Initially, MP was not found to have a negative effect on fungal growth and MET degradation. After 72 h of cultivation, the content of fungal biomass in samples with MPs was almost three times higher than that in the cultures without MPs. Additionally, a 75% degradation of the initial MET was observed. However, due to the qualitative and quantitative changes in individual classes of phospholipids, cell membrane permeability was increased. Additionally, MPs induced the overproduction of reactive oxygen species. The activity of superoxide dismutase and catalase was also increased in response to MPs. Despite these defense mechanisms, there was enhanced lipid peroxidation in the cultures containing the LDPE microparticles. The results of the study may fill the knowledge gap on the influence of MPs on filamentous fungi. The findings will be helpful in future research on the biodegradation of contaminants coexisting with MPs in soil. Full article
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