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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cutting-Edge Advances in Transcriptional Therapy and Nucleic Acid-Based Therapeutics

edited by

Vincenza Barresi

submission deadline 10 Jul 2025 | Viewed by 111 | Submission Open

Keywords: antisense oligonucleotides (ASOs); siRNAs; peptide nucleic acids (PNAs); aptamers; transcriptional therapy; nanocarriers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Updates and Applications in Forensic Medicine

edited by

Eugenia Carnevali

submission deadline 15 Jul 2025 | 3 articles | Viewed by 2825 | Submission Open

Keywords: forensic genetics; forensic transcriptomics; mitochondrial DNA (mtDNA); next-generation sequencing (NGS); body fluid identification; environmental DNA analysis; forensic entomology; animal and plant forensics; forensic microbiology; paternity testing; time of death; advanced molecular autopsy; disaster victim identification (DVI); ancient DNA; biological age prediction; DNA phenotyping; ancestry; investigative genetic genealogy; ethics in forensic genetics; criminal database; DNA mixture interpretation; activity level; forensic bioinformatics; artificial intelligence; quality assurance

(This special issue belongs to the Section Molecular Biology)

Molecular Paradigm Iconoclasm

edited by

Vance G. Nielsen

submission deadline 15 Jul 2025 | 1 articles | Viewed by 446 | Submission Open

Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology

(This special issue belongs to the Section Biochemistry)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 15 Jul 2025 | Viewed by 148 | Submission Open

Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes

edited by Maria Victoria Preciado

submission deadline 15 Jul 2025 | Viewed by 144 | Submission Open

Keywords: virus evolution; immune response; host– virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics

(This special issue belongs to the Section Molecular Immunology)

Biomarkers for Cardiovascular Risk Prediction

edited by

Sanja Stankovic

submission deadline 18 Jul 2025 | 1 articles | Viewed by 1212 | Submission Open

Keywords: biomarker; cardiovascular disease; risk stratification; inflammation; vascular damage; micro-RNA; therapy; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Natural Bioactive Compounds: 3rd Edition

edited by

Letteria Minutoli

and

Giovanni Pallio

submission deadline 20 Jul 2025 | 22 articles | Viewed by 51652 | Submission Open

Keywords: inflammation; cytokines; ROS; oxidative stress; natural products; flavonoids; cannabinoids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Agents and Novel Drugs Use for the Oncological Diseases Treatment

edited by

Alexandra L. Zakharenko

and

Nadezhda S. Dyrkheeva

submission deadline 20 Jul 2025 | 18 articles | Viewed by 38170 | Submission Open

Keywords: anti-proliferative; cancer; molecular oncology; novel agents; off-label use; target therapy

(This special issue belongs to the Section Molecular Pharmacology)

Focus on Cartilage Biology

edited by

Jácome Bruges-Armas

submission deadline 20 Jul 2025 | 5 articles | Viewed by 22376 | Submission Open

Keywords: cartilage biology; signaling pathways; molecular genetics; osteoarthritis; inflammatory arthropaty; cartilage repair; microbioma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Paroxysmal Nocturnal Hemoglobinuria: Pathophysiology and Novel Therapeutic Approaches

edited by Jun-Ichi Nishimura

submission deadline 20 Jul 2025 | 7 articles | Viewed by 19200 | Submission Open

Keywords: paroxysmal nocturnal hemoglobinuria; complement; intravascular hemolysis; extravascular hemolysis; breakthrough hemolysis; terminal complement inhibitor; proxymal complement inhibitor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microalgal Molecules and Enzymes: 2nd Edition

edited by

Assunta Saide

and

Chiara Lauritano

submission deadline 20 Jul 2025 | 5 articles | Viewed by 17877 | Submission Open

Keywords: microalgae; bioactive molecules; gene expression; drug discovery; molecular mechanism; gene mining; enzymes; industrial applications

(This special issue belongs to the Section Molecular Microbiology)

Alcohol and Inflammation

edited by

María Candelaria Martín-González

and Emilio González-Reimers

submission deadline 20 Jul 2025 | 7 articles | Viewed by 17070 | Submission Open

Keywords: alcohol; inflammation; alcohol use disorder; alcoholic liver disease; liver disease; alcoholic hepatitis; liver injury; oxidative damage

(This special issue belongs to the Section Molecular Immunology)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes

edited by

Daniela Miricescu

submission deadline 20 Jul 2025 | 7 articles | Viewed by 16750 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β ; Ras/Raf/MEK/ERK; Wnt/β -catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

State-of-the-Art Molecular Pharmacology in USA

edited by

Anastasios Lymperopoulos

William C. (Trey) Putnam

Khosrow Kashfi

Kamyar Zahedi

and

Gaetano Santulli

submission deadline 20 Jul 2025 | 4 articles | Viewed by 16558 | Submission Open

Keywords: signal transduction; receptor; animal models; preclinical; pharmacodynamics; pharmacokinetics; drug development; drug metabolism

(This special issue belongs to the Section Molecular Pharmacology)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 Jul 2025 | 6 articles | Viewed by 15816 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Pro-inflammatory and Anti-inflammatory Interleukins in Various Diseases 2.0

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 20 Jul 2025 | 6 articles | Viewed by 14882 | Submission Open

Keywords: cytokines; inflammation; interleukins; IL-1; IL-2; IL-3; IL-4; IL-5; IL-6; IL-7; IL-8; IL-9; IL-10; IL-11; IL-12; IL-17; IL-18; IL-22; IL-37; IL-38; IFN-α ; IFN-β ; IFN-γ ; TGF-β ; TNF-α ; TNF-β ; allergy; TNF-α ; chemokines; interferon; gut inflammation; systemic inflammation; infection

(This special issue belongs to the Section Molecular Immunology)

Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression

edited by Sonam Mittal

submission deadline 20 Jul 2025 | 6 articles | Viewed by 14418 | Submission Open

Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Lung Cancers: An Update on Molecular Diagnostics and Therapy

edited by

Mariusz Chabowski

submission deadline 20 Jul 2025 | 6 articles | Viewed by 13992 | Submission Open

Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases 2.0

edited by

Yasemin M. Akay

submission deadline 20 Jul 2025 | 6 articles | Viewed by 13437 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Peripheral Nerve Regeneration

edited by

Cinzia Fabrizi

submission deadline 20 Jul 2025 | 7 articles | Viewed by 13056 | Submission Open

Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Therapies of Chronic Obstructive Pulmonary Disease

edited by

Marija Stankovic

submission deadline 20 Jul 2025 | 6 articles | Viewed by 12980 | Submission Open

Keywords: COPD; molecular mechanism; inflammation; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Dysbiosis in Chronic Diseases

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12883 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; microorganism; metabolites; clinical practices; prebiotics; probiotics

(This special issue belongs to the Section Molecular Microbiology)

Mitochondrial Dysfunction in Autoimmune Diseases

edited by

Biji Theyilamannil Kurien

submission deadline 20 Jul 2025 | 1 articles | Viewed by 12467 | Submission Open

Keywords: autoimmune diseases; autoantibodies; autophagy; mitophagy; mitochondrial hyperpolarization; mitochondrial dysfunction; oxidative phosphorylation; oxidative damage; fatigue; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Aryl Hydrocarbon Receptor in Immune Modulation

edited by

Jörg Lehmann

submission deadline 20 Jul 2025 | 5 articles | Viewed by 12441 | Submission Open

(This special issue belongs to the Section Biochemistry)

Advances in Tomato Breeding and Molecular Research

edited by Silvana Grandillo,

Gianfranco Diretto

and

Maria Cammareri

submission deadline 20 Jul 2025 | 6 articles | Viewed by 12404 | Submission Open

Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 3rd Edition

edited by

Yutang Wang

and

Dianna Magliano

submission deadline 20 Jul 2025 | 6 articles | Viewed by 12306 | Submission Open

Keywords: cardiovascular disease; myocardial infarction; stroke; transient ischaemic attack; hypertension; diabetes mellitus; atherosclerosis; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurometabolic Disorders in the Adults

edited by

Klary Niezen-Koning

and

Tom J. de Koning

submission deadline 20 Jul 2025 | 4 articles | Viewed by 12058 | Submission Open

Keywords: Neurometabolic; Metabolic/biochemical pathways; Genetic defects; Pathological phenotypes

(This special issue belongs to the Section Molecular Neurobiology)

Exploring Molecular Mechanisms of Inflammatory Diseases

edited by

Vlatka Sotosek

submission deadline 20 Jul 2025 | 4 articles | Viewed by 11821 | Submission Open

Keywords: immunity; inflammation; inflammatory disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Steroid Biosynthesis and Metabolism

edited by Amanda C. Swart

submission deadline 20 Jul 2025 | 6 articles | Viewed by 11769 | Submission Open

Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Gene Doping Control

edited by

Teruaki Tozaki

submission deadline 20 Jul 2025 | 5 articles | Viewed by 11729 | Submission Open

Keywords: cell therapy; cell doping; gene doping; gene editing; gene silencing; gene therapy; transgene; CRISPR; therapeutic oligonucleotide

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 4th Edition

edited by

Grzegorz Wegrzyn

submission deadline 20 Jul 2025 | 7 articles | Viewed by 11297 | Submission Open

Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?

edited by

Dimitrios Kanakis

submission deadline 20 Jul 2025 | 5 articles | Viewed by 11245 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD）; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Cell Division: A Focus on Molecular Mechanisms

edited by Stefano Sechi and Antonino Colanzi

submission deadline 20 Jul 2025 | 7 articles | Viewed by 11110 | Submission Open

Keywords: cell cycle; cell division; post-translational modification (PTM); mitosis/meiosis; cell organelles; cytokinesis; membrane trafficking; disease; therapeutic target; model organisms

(This special issue belongs to the Section Molecular Biology)

Liver Diseases: From Molecular Basis to Potential Therapy

edited by

Giuliano Ramadori

submission deadline 20 Jul 2025 | 5 articles | Viewed by 11017 | Submission Open

Keywords: TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Network Pharmacology: An Emerging Field in Drug Discovery

edited by

Weiwei Han

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10892 | Submission Open

Keywords: network pharmacology; machine learning; databases; drug discovery; computer-aided drug design (CADD); data mining

(This special issue belongs to the Section Molecular Pharmacology)

Sphingolipid Metabolism and Signaling in Health and Diseases

edited by Gergana M. Deevska

submission deadline 20 Jul 2025 | 5 articles | Viewed by 10886 | Submission Open

Keywords: ceramide; ceramide-1-phosphate; sphingosine; sphingosine-1-phosphate; sphingomyelin; glycosphingolipids; metabolic syndrome; obesity; diabetes; cancer; neurodegeneration; neuroinflammation; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Immune-Inflammatory and Oxidative Stress Signaling Pathways Involved in Human Disorders

edited by

Alessio Ardizzone

and

Emanuela Esposito

submission deadline 20 Jul 2025 | 3 articles | Viewed by 10821 | Submission Open

Keywords: inflammation; neuroinflammation; immune system; oxidative stress

(This special issue belongs to the Section Molecular Immunology)

Neurotrophins: Roles and Function in Human Diseases 2.0

edited by

Marco Fiore

submission deadline 20 Jul 2025 | 4 articles | Viewed by 10652 | Submission Open

Keywords: neuroinflammation; brain; toxicology; cell growth; neurogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Cell Signaling Pathways and Signal Transduction

edited by Katsuhiko Muraki and

Susumu Ohya

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10554 | Submission Open

Keywords: Ca2+ signaling; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell metabolism; cell senescence; protein phosphorylation/dephosphorylation; membrane trafficking; cell proliferation; differentiation; and apoptosis; cytokine/chemokine signaling

(This special issue belongs to the Section Biochemistry)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Jul 2025 | 4 articles | Viewed by 10440 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-Alcoholic Fatty Liver Disease (NAFLD): 2nd Edition

edited by

Eva Kassi

Ioannis Kyrou

and

Harpal S. Randeva

submission deadline 20 Jul 2025 | 7 articles | Viewed by 10122 | Submission Open

Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 2nd Edition

edited by

Shanfa Lu

submission deadline 20 Jul 2025 | 9 articles | Viewed by 10096 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Medicinal Plants and Natural Products

edited by

Ana Paula Coelho Duarte

and

Ângelo Luís

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10060 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Hormone Signaling

edited by

Ewa Muszyńska

and

Kinga Dziurka

submission deadline 20 Jul 2025 | 8 articles | Viewed by 10032 | Submission Open

Keywords: hormonal regulation; cross-talk between phytohormones and other metabolites; signaling; gene expression; defense mechanisms; abiotic and biotic stress; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into the Effects of Microbiome-Derived Metabolites on Health and Disease

edited by Kinga Jaworska

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9865 | Submission Open

Keywords: bacterial metabolites; short-chain fatty acids; trimethylamine N-oxide; gut microbiome; molecular pathways; intestinal barrier

(This special issue belongs to the Section Molecular Microbiology)

Research in iPSC-Based Disease Models

edited by

Eric Deneault

submission deadline 20 Jul 2025 | 6 articles | Viewed by 9781 | Submission Open

Keywords: iPSCs; disease model; organoid; gene editing; mutation correction; isogenic control

(This special issue belongs to the Section Molecular Biology)

Endothelial Dysfunction and Cardiovascular Diseases

edited by

Olga Kruszelnicka

submission deadline 20 Jul 2025 | 4 articles | Viewed by 9734 | Submission Open

Keywords: chemokines; cytokines; leukocyte trafficking; leukocyte attracting; leukocyte-derived cytokines; nitric oxide; prostacyclin; adhesion molecules; endothelium

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Head and Neck and Skin Cancer

edited by

Nerina Denaro

Gianluca Nazzaro

and Iorio Giuseppe Carlo

submission deadline 20 Jul 2025 | 3 articles | Viewed by 9406 | Submission Open

Keywords: head and neck cancer; melanoma; nonmelanoma skin cancer; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Molecular Mediators of Exercise: Cross-Organ Communication Promoting Health and Combating Disease

edited by

Jan Bilski

and

Tomasz Brzozowski

submission deadline 20 Jul 2025 | 4 articles | Viewed by 9392 | Submission Open

Keywords: exercise physiology; adipokines; myokines; hepatokines; inter-organ communication; inflammation; insulin sensitivity; obesity; type 2 diabetes; gastrointestinal system; cardiovascular system; sarcopenia; aging; osteogenic regulation; neurological health; nutraceuticals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Neurotransmitters

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9379 | Submission Open

Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 1001-1050 on page 21 of 69.

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