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Pro-inflammatory and Anti-inflammatory Interleukins in Various Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1794

Special Issue Editors


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Guest Editor
Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland
Interests: biochemistry; opioid peptides; food proteins; vitamins; nutrition; allergy; autoimmune; neurodevelopmental diseases; nutrigenomics; nutricosmetics; cosmeceuticals; dermocosmetics

Special Issue Information

Dear Colleagues,

Cytokines are crucial in modulating the immune system, and as key modulators of inflammation, are produced in response to infection. Proinflammatory cytokines are positive mediators of inflammation, and anti-inflammatory cytokines are immunoregulatory molecules that control the pro-inflammatory cytokine response. Certain cytokines are involved in not only the initiation but also the progression/regression of diseases.

In this Special Issue of the International Journal of Molecular Sciences, we aim to focus on the latest discoveries and developments in pro-inflammatory and anti-inflammatory interleukins, their relation with diseases in animals and human studies, and the possible underlying mechanisms, thereby supplementing the existing literature on this field. Therefore, we cordially invite scholars from basic, immunological, pathophysiological, nutritional and metabolism research or other related disciplines to submit their original articles, reviews, communications, as well as conceptual papers to this Special Issue.

Dr. Anna Cieślińska
Dr. Edyta Sienkiewicz-Szłapka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytokines
  • inflammation
  • interleukins
  • IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-17, IL-18, IL-22, IL-37, IL-38, IFN-α, IFN-β, IFN-γ, TGF-β, TNF-α, TNF-β
  • allergy
  • TNF-α
  • chemokines
  • interferon
  • gut inflammation
  • systemic inflammation
  • infection

Published Papers (2 papers)

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Research

11 pages, 2912 KiB  
Article
miR-146a Decreases Inflammation and ROS Production in Aged Dermal Fibroblasts
by Liping Zhang, Iris C. Wang, Songmei Meng and Junwang Xu
Int. J. Mol. Sci. 2024, 25(13), 6821; https://doi.org/10.3390/ijms25136821 - 21 Jun 2024
Viewed by 176
Abstract
Aging is associated with a decline in the functionality of various cell types, including dermal fibroblasts, which play a crucial role in maintaining skin homeostasis and wound healing. Chronic inflammation and increased reactive oxygen species (ROS) production are hallmark features of aging, contributing [...] Read more.
Aging is associated with a decline in the functionality of various cell types, including dermal fibroblasts, which play a crucial role in maintaining skin homeostasis and wound healing. Chronic inflammation and increased reactive oxygen species (ROS) production are hallmark features of aging, contributing to impaired wound healing. MicroRNA-146a (miR-146a) has been implicated as a critical regulator of inflammation and oxidative stress in different cell types, yet its role in aged dermal fibroblasts and its potential relevance to wound healing remains poorly understood. We hypothesize that miR-146a is differentially expressed in aged dermal fibroblasts and that overexpression of miR-146a will decrease aging-induced inflammatory responses and ROS production. Primary dermal fibroblasts were isolated from the skin of 17-week-old (young) and 88-week-old (aged) mice. Overexpression of miR-146a was achieved through miR-146a mimic transfection. ROS were detected using a reliable fluorogenic marker, 2,7-dichlorofluorescin diacetate. Real-time PCR was used to quantify relative gene expression. Our investigation revealed a significant reduction in miR-146a expression in aged dermal fibroblasts compared to their younger counterparts. Moreover, aged dermal fibroblasts exhibited heightened levels of inflammatory responses and increased ROS production. Importantly, the overexpression of miR-146a through miR-146a mimic transfection led to a substantial reduction in inflammatory responses through modulation of the NF-kB pathway in aged dermal fibroblasts. Additionally, the overexpression of miR-146a led to a substantial decrease in ROS production, achieved through the downregulation of NOX4 expression in aged dermal fibroblasts. These findings underscore the pivotal role of miR-146a in mitigating both inflammatory responses and ROS production in aged dermal fibroblasts, highlighting its potential as a therapeutic target for addressing age-related skin wound healing. Full article
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19 pages, 3963 KiB  
Article
The Effect of Orally Administered Multi-Strain Probiotic Formulation (Lactobacillus, Bifidobacterium) on the Phagocytic Activity and Oxidative Metabolism of Peripheral Blood Granulocytes and Monocytes in Lambs
by Roman Wójcik, Joanna Małaczewska, Dawid Tobolski, Jan Miciński, Edyta Kaczorek-Łukowska and Grzegorz Zwierzchowski
Int. J. Mol. Sci. 2024, 25(10), 5068; https://doi.org/10.3390/ijms25105068 - 7 May 2024
Viewed by 787
Abstract
Probiotic feed additives have attracted considerable research interest in recent years because the effectiveness of probiotics can differ across microbial strains and the supplemented macroorganisms. The present study was conducted on 16 lambs divided equally into two groups (C—control and E—experimental). The examined [...] Read more.
Probiotic feed additives have attracted considerable research interest in recent years because the effectiveness of probiotics can differ across microbial strains and the supplemented macroorganisms. The present study was conducted on 16 lambs divided equally into two groups (C—control and E—experimental). The examined lambs were aged 11 days at the beginning of the experiment and 40 days at the end of the experiment. The diet of group E lambs was supplemented with a multi-strain probiotic formulation (Lactobacillus plantarum AMT14, Lactobacillus plantarum AMT4, Lactobacillus rhamnosus AMT15, and Bifidobacterium animalis AMT30), whereas group C lambs did not receive the probiotic additive. At the beginning of the experiment (day 0) and on experimental days 15 and 30, blood was sampled from the jugular vein to determine and compare: phagocytic activity (Phagotest) and oxidative metabolism (Phagoburst) of peripheral blood granulocytes and monocytes by flow cytometry. An analysis of the phagocytic activity of granulocytes and monocytes revealed significantly higher levels of phagocytic activity (expressed as the percentage of phagocytic cells and mean fluorescence intensity) in lambs that were administered the multi-strain probiotic formulation compared with lambs in the control group. The probiotic feed additive also exerted a positive effect on the oxidative metabolism of both granulocytes and monocytes (expressed as the percentage of oxidative metabolism and mean fluorescence intensity) after stimulation with Escherichia coli bacteria and with PMA (4-phorbol-12-β-myristate-13-acetate). These findings suggest that the tested probiotic formulation may have a positive effect on the immune status of lambs. Full article
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