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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plasticity in Multiple Sclerosis: From Molecular to System Level, from Adaptation to Maladaptation
edited by Gloria Dalla Costa and Laura Cacciaguerra
submission deadline 20 Feb 2026 | Viewed by 93 | Submission Open
Keywords: multiple sclerosis; neuroplasticity; remyelination; synaptic adaptations
(This special issue belongs to the Section Molecular Neurobiology)
Development and Applications of Biodegradable and Bioactive Materials submission deadline 20 Feb 2026 | Viewed by 88 | Submission Open
Keywords: biopolymers; bioplastics; sustainability; food packaging; medicine and cosmetic; bioactive compounds; wound healing; active and intelligent packaging
(This special issue belongs to the Section Materials Science)
The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development
edited by Gabriela Verónica Salamone
submission deadline 20 Feb 2026 | Viewed by 84 | Submission Open
Keywords: gliomas tumor microenvironment immune
(This special issue belongs to the Section Molecular Oncology)
Advancements in the Electrochemical Detection of Biomolecules: From Sensing to Environmental Applications
edited by
submission deadline 20 Feb 2026 | Viewed by 61 | Submission Open
Keywords: biomolecules; nanomaterials; biorecognition; biomolecular detection; electrochemical
(This special issue belongs to the Section Molecular Biophysics)
Biosensors: Emerging Technologies and Real-Time Monitoring
edited by
submission deadline 20 Feb 2026 | Viewed by 54 | Submission Open
Keywords: biosensors; real-time monitoring; wearable sensors; electrochemical detection; optical biosensors; point-of-care (POC) diagnostics; biomarker identification and analysis; wireless technologies
(This special issue belongs to the Section Biochemistry)
Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions: 2nd Edition
edited by Vija Lavinia
submission deadline 20 Feb 2026 | Viewed by 35 | Submission Open
Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
AIEgens in Action: Design, Mechanisms, and Emerging Applications submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open
Keywords: fluorescence effects; photophysical properties of small molecules; ion detection; molecular spectroscopy; various nanoparticle-based additives; fluorescent and phosphorescent phenomena in solvents; amorphous states; and crystals; quantum-mechanical calculations for molecular systems and compositions (DFT; TD-DFT); molecular aggregation influencing fluorescence and phosphorescence properties of tested systems
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Transcriptional Regulation and Its Misregulation in Human Diseases: Recent Insights submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open
Keywords: transcription machinery; transcription (co)factors; chromatin regulators; splicing regulators; noncoding RNAs; transcription misregulation; genetic alterations; human diseases; transcriptome profiling; bioinformatics analysis
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Gestational Diabetes Mellitus: 2nd Edition
edited by Natasha Singh
submission deadline 20 Feb 2026 | Viewed by 19 | Submission Open
Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Vector-Mediated Genome Editing Therapy
edited by
submission deadline 20 Feb 2026 | Viewed by 15 | Submission Open
Keywords: genome editing; adenovirus vector; knock-in; inherited disease; viral vectors
(This special issue belongs to the Section Molecular Genetics and Genomics)
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