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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Integrative Regenerative Medicine: Bridging Molecular Mechanisms and Therapeutic Applications

edited by Jerran Santos

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: regenerative medicine; stem cells; molecular mechanisms; tissue engineering; organoids; biomaterials; biofabrication; clinical translation; cell therapy; integrative biology

(This special issue belongs to the Section Molecular Biology)

Mechanistic Insights into the Ubiquitin System’s Role in Cellular Signal Transduction and Homeostasis

edited by Michael Massiah

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: ubiquitination; protein homeostasis; deubiquitinases; E3-associated diseases; autophagy; ubiquitin dysregulation; proteasome-targeting; protac

(This special issue belongs to the Section Molecular Biology)

Advances in Neurorepair and Regeneration

edited by

Andrei Gresita

and Tiago Santos

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: neurorepair; regeneration; neuroplasticity; cellular reprogramming; biomaterials; stroke; spinal cord injury; traumatic brain injury; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring the Gut-Brain Axis: Mechanisms and Implications for Health and Disease

edited by

Martina Vincenzi

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: gut– brain axis; enteric nervous system; dysbiosis; gut microbiota; neuroinflammation; one health; microbiota– immune crosstalk; metabolic syndromes; cardiovascular diseases; neurodegenerative diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic and Epigenetic Determinants of Circulating Cell-Free DNA Release in Cancer

edited by

Federica Maione

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: genomic alterations; epigenetic modifications; chromosomal instability; aneuploidy and DNA fragmentation; tumor cell-derived cell-free DNA release; chromosome methylation; liquid biopsy; gene-gene interactions; cell death

(This special issue belongs to the Section Molecular Oncology)

Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 30 Apr 2026 | Viewed by 16 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

Biomass as Feedstock for the Production of High Value-Added Chemicals by Heterogeneous Catalysis

edited by

Cristina García-Sancho

submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open

Keywords: biomass; heterogeneous catalysts; biofuels; bioproducts; platform molecules

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Advances in Sperm Physiology and Genetics

edited by Jordi Ribas-Maynou and Ariadna Delgado Bermudez

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: sperm; DNA; chromatin; physiology; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

Bioactive Phenolic Compounds in Human Health and Disease: Second Edition

edited by

Andrei Lobiuc

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: novel sources; synthesis; biological activity; molecular interactions; pharmacodynamics; pharmacokinetics; assay development; microbiota; sources and intake

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Orofacial Pain and Headache

edited by Adriana Elena Bulboaca

submission deadline 30 Apr 2026 | Viewed by 11 | Submission Open

Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition

edited by

George Miloshev

submission deadline 30 Apr 2026 | Viewed by 4 | Submission Open

Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging

(This special issue belongs to the Section Molecular Pharmacology)

Neural Circuit Mechanisms of Brain Disorders

edited by

Yun Li

submission deadline 30 Apr 2026 | Submission Open

Keywords: dynamic wiring; brain network; brain connectivity; neuropathology; neuromodulation; neuroplasticity; circuit mapping

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 30 Apr 2026 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host– microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Artificial Intelligence, Machine Learning, and Bioinformatics in Molecular Mechanisms of Human Health and Disease

edited by

Santosh Anand

submission deadline 30 Apr 2026 | Submission Open

Keywords: artificial intelligence; machine learning; bioinformatics; molecular mechanisms; human health; human disease; multi-omics data; molecular pathways; personalized medicine; disease biomarkers

(This special issue belongs to the Section Molecular Informatics)

Advances on Viral Immunology and Pathogenesis of Viral Infections

edited by Yeong-Bin Baek

submission deadline 30 Apr 2026 | Submission Open

Keywords: viral immunology; viral pathogenesis; innate sensing and interferon; cytokine networks and inflammasomes; adaptive immunity (T- and B-cell quality); immunometabolism and lipid signaling; host-directed antiviral strategies; transcriptomics and spatial omics; mechanism of action and target engagement; complex bioactive modulators

(This special issue belongs to the Section Molecular Microbiology)

From Molecular Insights to Novel Therapies: Neurological Diseases

edited by

Margarita Neganova

submission deadline 20 May 2026 | 17 articles | Viewed by 59704 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapy for Immune Diseases

edited by

Alexey Sarapultsev

submission deadline 20 May 2026 | 15 articles | Viewed by 45626 | Submission Open

Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Fascial Anatomy and Histology: Advances in Molecular Biology

edited by

Carla Stecco

submission deadline 20 May 2026 | 4 articles | Viewed by 26402 | Submission Open

Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 May 2026 | 6 articles | Viewed by 23776 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin

edited by Radoslaw Zajdel

submission deadline 20 May 2026 | 2 articles | Viewed by 21438 | Submission Open

Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovative Nanomaterials from Functional Molecules

edited by Xiaoming Zhang and

Yi Jia

submission deadline 20 May 2026 | 4 articles | Viewed by 14418 | Submission Open

Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Melanoma and Skin Cancers: 2nd Edition

edited by

Domenico Mallardo

Debora Basile

and Maria Grazia Vitale

submission deadline 20 May 2026 | 6 articles | Viewed by 12421 | Submission Open

Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy

(This special issue belongs to the Section Molecular Oncology)

The Roles of Photodynamic Therapy in Tumors and Cancers

edited by Jianyong Liu

submission deadline 20 May 2026 | 4 articles | Viewed by 10577 | Submission Open

Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer

(This special issue belongs to the Section Molecular Oncology)

Pathogenesis and Novel Therapeutic Approaches for Sarcomas

edited by Francisco Giner

submission deadline 20 May 2026 | 4 articles | Viewed by 10334 | Submission Open

Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment

edited by Manuel Morales-Ruiz

submission deadline 20 May 2026 | 5 articles | Viewed by 10169 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways; diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling; cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Oxidative Stress and Antioxidants in Human Disease

edited by

Federica Mannino

submission deadline 20 May 2026 | 6 articles | Viewed by 10140 | Submission Open

Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration

edited by

Sara Cruciani

submission deadline 20 May 2026 | 6 articles | Viewed by 10051 | Submission Open

Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition

edited by

Donatella Delle Cave

submission deadline 20 May 2026 | 7 articles | Viewed by 9214 | Submission Open

Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine

(This special issue belongs to the Section Molecular Oncology)

New Cardiovascular Risk Factors: 2nd Edition

edited by

Antonio Barbato

submission deadline 20 May 2026 | 4 articles | Viewed by 8732 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Biology)

Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies

edited by

Charles Manful

submission deadline 20 May 2026 | 3 articles | Viewed by 8269 | Submission Open

Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutting-Edge Methods for Exploiting Bioactive Compounds in Biomasses: From the Plant Matrix to Molecular Function

edited by Chiara Magni

submission deadline 20 May 2026 | 5 articles | Viewed by 8196 | Submission Open

Keywords: plant matrix; agri-food biomasses; biochemistry; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Impact of Mitochondria on Human Disease and Health

edited by

Martina Semenzato

submission deadline 20 May 2026 | 5 articles | Viewed by 7906 | Submission Open

Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer

(This special issue belongs to the Section Biochemistry)

Fish Immunology, 5th Edition

edited by

Alberto Cuesta

and

Elena Chaves-Pozo

submission deadline 20 May 2026 | 4 articles | Viewed by 7832 | Submission Open

Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation

(This special issue belongs to the Section Molecular Immunology)

Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy

edited by

Tetiana Zaǐchuk

submission deadline 20 May 2026 | 5 articles | Viewed by 7145 | Submission Open

Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution

(This special issue belongs to the Section Molecular Oncology)

Macrophages and Inflammation

edited by

Julia Kzhyshkowska

submission deadline 20 May 2026 | 2 articles | Viewed by 7084 | Submission Open

Keywords: innate immunity; transcriptional programs; epigenetics; immunometabolism; receptors; scavenging; cytokines; ROS

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Treatment of Migraine

edited by Noboru Imai

submission deadline 20 May 2026 | 1 articles | Viewed by 7063 | Submission Open

Keywords: migraine; nitric oxide synthase (NOS); neuropeptides; calcitonin gene-related peptide (CGRP); pituitary adenylate cyclase activating polypeptide (PACAP); molecular pathways; therapeutic targets; neurovascular condition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioprinting: Progress and Challenges

edited by

Rui Vitorino

submission deadline 20 May 2026 | 1 articles | Viewed by 6774 | Submission Open

Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research

(This special issue belongs to the Section Materials Science)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 20 May 2026 | 4 articles | Viewed by 6746 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

Bioactive Compound Delivery Systems and Microbiome Interactions

edited by

Ramona Suharoschi

Adriana Fodor

and

Oana Lelia Pop

submission deadline 20 May 2026 | 2 articles | Viewed by 6620 | Submission Open

Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition

edited by

Klaus H. Hoffmann

submission deadline 20 May 2026 | 3 articles | Viewed by 6571 | Submission Open

Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology

(This special issue belongs to the Section Molecular Immunology)

Advances in G Protein-Coupled Receptor Signaling

edited by

Dariusz Szukiewicz

submission deadline 20 May 2026 | 1 articles | Viewed by 6570 | Submission Open

Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗

(This special issue belongs to the Section Molecular Immunology)

New Advances in Opioid Research

edited by Matthew E. Layton

submission deadline 20 May 2026 | 5 articles | Viewed by 5697 | Submission Open

Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes

(This special issue belongs to the Section Molecular Pharmacology)

Technical Developments and Recent Applications of Cellular Molecular Imaging

edited by Hanae Sato

submission deadline 20 May 2026 | 3 articles | Viewed by 5585 | Submission Open

Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals

edited by

Roberta Macri

submission deadline 20 May 2026 | 1 articles | Viewed by 5570 | Submission Open

Keywords: cardiovascular disease; drugs; nutrients

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Natural Compounds in Cancer and Inflammation, 2nd Edition

edited by

Elia Ranzato

submission deadline 20 May 2026 | 4 articles | Viewed by 5471 | Submission Open

Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics

edited by

Elisabetta Ferrara

submission deadline 20 May 2026 | 2 articles | Viewed by 5447 | Submission Open

Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biological and Molecular Targets in Schizophrenia

edited by Jacopo Sapienza

submission deadline 20 May 2026 | 4 articles | Viewed by 5072 | Submission Open

Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 20 May 2026 | 3 articles | Viewed by 4942 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds

edited by

Kiril Gavazov

submission deadline 20 May 2026 | 5 articles | Viewed by 4936 | Submission Open

Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Displaying special issue 3101-3150 on page 63 of 69.

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