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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Therapeutic Targets in Cancers: 3rd Edition

edited by

Elena Levantini

submission deadline 20 Aug 2025 | 6 articles | Viewed by 12338 | Submission Open

Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Epigenetic Genes, Biomarkers and Immunotherapy in Cancers

edited by

Urszula Oleksiewicz

and

Andrzej Mackiewicz

submission deadline 20 Aug 2025 | 5 articles | Viewed by 11977 | Submission Open

Keywords: epigenetics; epigenetic modifications; immunotherapies; immune checkpoint; DNA methylation; histone modifications; epigenetic biomarkers; epidrugs; endogenous retroviruses

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Advances in Endometriosis Research: 3rd Edition

edited by

Antonio Simone Laganà

submission deadline 20 Aug 2025 | 3 articles | Viewed by 11814 | Submission Open

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Innovative Strategies to Target Metabolism, Inflammation, and Oxidative Stress in Human Diseases

edited by

Kota V. Ramana

submission deadline 20 Aug 2025 | 11 articles | Viewed by 11677 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; aging; cardiovascular diseases; gene editing; stem cell therapy; next-generation sequencing; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Regulation in Chronic Kidney Diseases

edited by

Marijn Speeckaert

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11621 | Submission Open

Keywords: chronic kidney disease; pathophysiology; genetic and epigenetic factors; metabolic and inflammatory pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Disorders: Molecular Pathology and Therapeutic Approaches

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11569 | Submission Open

Keywords: The following topics are proposed for this SI:Intracellular signalling networks in neurological disorders.Identification of new therapeutic targets.Genetics of neurological disorders: identification and treatment of mutations.Mitochondrial diseases and neurodegeneration.Gene therapy in neurological diseases: recent advances.Neuroinflammation in autoimmune disorders of the central nervous system.Impact of the microbiome on neurological health.

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Epigenetic Modifications

edited by

Marco Miceli

, Mariella Cuomo and

Rosa Della Monica

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11565 | Submission Open

Keywords: epigenetic modifications; chromatin remodeling; transcription factors; RNA modification; histones; methylation; diseases; epigenetic drugs development

(This special issue belongs to the Section Molecular Genetics and Genomics)

Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights

edited by

Ramona Suharoschi

Oana Lelia Pop

and

Adriana Fodor

submission deadline 20 Aug 2025 | 3 articles | Viewed by 11555 | Submission Open

Keywords: phytochemicals; antioxidant activities; anti-inflammatory properties; antimicrobial effects; molecular mechanisms; clinical applications; traditional medicine; bioavailability; safety and toxicology and regulatory aspects of phytochemicals; pharmacological interaction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Glycosaminoglycans in Human Diseases

edited by

Darko Kero

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11526 | Submission Open

Keywords: glycosaminoglycans; inflammation; infectious disease; cancer

(This special issue belongs to the Section Biochemistry)

New Insights into CKD and Age-Related Bone and Mineral Disorders

edited by

Natalia Carrillo-López

Sara Panizo

and

Cristina Alonso-Montes

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11475 | Submission Open

Keywords: chronic kidney disease; CKD; CKD-MBD; mineral and bone disorder

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Cancer Immunotherapies—2nd Edition

edited by

Takayuki Yoshimoto

Takuma Kato

and

Hisashi Nagase

submission deadline 20 Aug 2025 | 5 articles | Viewed by 11061 | Submission Open

Keywords: immune checkpoint inhibitors; antibody therapy; cytokines/chemokines; CAR-T and TCR-T cells; iPS cell-derived cells; dendritic cell therapy; vaccine; inflammation; mesenchymal stem cells; immunosuppressive tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Novel Molecular Targets and Prognostic Markers Focused on Improving Quality in Healthcare

edited by

Ion Cristóbal

submission deadline 20 Aug 2025 | 6 articles | Viewed by 10976 | Submission Open

Keywords: prognostic markers; molecular targets; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Calcium Metabolism and Regulation

edited by Hermann Salmhofer and

Michael Lichtenauer

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10677 | Submission Open

Keywords: pathologic calcification; calcification inhibitors; calciprotein particles; Runx-2; apatite; matrix Gla protein; fetuin-A; vitamin D; parathyroid hormone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Research on Protein Structure and Protein Dynamics

edited by

Robert T. Youker

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10637 | Submission Open

Keywords: allostery; receptor; kinase; protein folding; simulations; X-ray crystallography; NMR; super-resolution imaging; fluorescence fluctuation techniques; thermodynamic; enzyme; catalysis; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Gastrointestinal Cancer: From Pathophysiology to Novel Therapeutic Approaches

edited by

Marlena Brzozowa-Zasada

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10457 | Submission Open

Keywords: gastrointestinal cancer; molecular pathology; innovative therapies; targeted therapy; immunotherapy; cancer resistance

(This special issue belongs to the Section Molecular Oncology)

Advances in Rare Diseases Biomarkers: 2nd Edition

edited by

Andrea Bernini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10252 | Submission Open

Keywords: orphan diseases; rare diseases; inborn errors of metabolism; mitochondrial disorders; biomarker discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular and Cellular Research in Ophthalmology

edited by Zala Lužnik Marzidovšek

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10174 | Submission Open

Keywords: eye disease; ophthalmology; molecular mechanisms; cellular mechanism; stem cell therapy; tissue engineering; gene therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases

edited by

Pauline Po Yee Lui

submission deadline 20 Aug 2025 | 2 articles | Viewed by 9984 | Submission Open

Keywords: tendinopathy; tendon pain; stiffness; physical disability; etiopathogenesis; molecular mechanisms; tendon reattachment; tendon repair; advanced molecular tools; omics techniques; biophysical therapies; novel biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Study and Treatment of Motor Neuron Diseases

edited by Simona Rossi and

Savina Apolloni

submission deadline 20 Aug 2025 | 3 articles | Viewed by 9945 | Submission Open

Keywords: motor neuron; amyotrophic lateral sclerosis; neuronal degeneration; pathogenic mechanisms; molecular therapy

(This special issue belongs to the Section Molecular Neurobiology)

The Na, K-ATPase in Health and Disease

edited by

Liora Shoshani

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9876 | Submission Open

Keywords: Na+; K+-ATPase; α -subunit; β -subunit; γ subunits; FXYD

(This special issue belongs to the Section Molecular Biology)

Advances in Immunology and Inflammation During and After Infectious Diseases

edited by

Manuela Ceccarelli

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9817 | Submission Open

Keywords: bacterial infections; fungi infections; HIV; COVID-19; immune response; inflammation

(This special issue belongs to the Section Molecular Immunology)

Oxidative Stress and Inflammation in Health and Disease

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9722 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; risk factors; prevention

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Derived Food Products in the Prevention of Chronic Non-Communicable Diseases

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 20 Aug 2025 | 7 articles | Viewed by 9676 | Submission Open

Keywords: plant foods; plant-derived foods; oxidative stress; bioactive compounds; antioxidative substances; chronic non-communicable diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances of Natural Products in Chemical and Biological Aspects

edited by

Francisco Les

Marta Sofía Valero

and

María Pilar Arruebo

submission deadline 20 Aug 2025 | 6 articles | Viewed by 9638 | Submission Open

Keywords: bioactive compounds; polyphenols; antioxidants; natural products; phytochemicals; molecular research; chemical composition; therapeutic targets; action mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biomarkers of Tumor Progression, Prognosis and Therapy: 2nd Edition

edited by

Tibor Krenacs

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9310 | Submission Open

Keywords: cancer biomarkers; genetic aberrations; carcinogenesis; cancer progression; molecular methods; in silico data analysis; image analysis; proteomics

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Treatments in Neurodegenerative Diseases

edited by

Ermanna Turano

and

Raffaella Mariotti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9303 | Submission Open

Keywords: neurodegenerative diseases; regenerative therapy; neuroprotection; neurodegeneration; pathogenetic mechanisms; cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Microbial Enzymes for Biotechnological Applications: 2nd Edition

edited by

Salvatore Fusco

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9284 | Submission Open

Keywords: microbial enzymes; whole-cell biocatalysts; extremozyme; enzyme assays; protein engineering

(This special issue belongs to the Section Biochemistry)

Neurodegenerative Diseases: New Insights into Mechanisms, Prevention, Markers, and Therapeutic Targets

edited by

Katarzyna Kaczyńska

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9098 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; molecular targets; biomarkers; disease modeling; therapeutic strategies; prevention; drug design

(This special issue belongs to the Section Molecular Neurobiology)

Autophagy and Cellular Oxidative Stress: Molecular Mechanisms and Diagnostic Biomarkers

edited by Ramona D’Amico and

Daniela Impellizzeri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 9056 | Submission Open

Keywords: autophagy; oxidative stress; biomarkers; acute and chronic diseases; molecular pathways; ROS; mitophagy

(This special issue belongs to the Section Molecular Biology)

The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence

edited by

Angelo Montana

and

Margherita Neri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8935 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Therapeutic Uses of Adult Stem Cells

edited by Leonard M. Eisenberg and Carol A. Eisenberg

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8823 | Submission Open

Keywords: adult stem cells; mesenchymal stem cells; immune response; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Wound Healing: 2nd Edition

edited by

Alina Maria Holban

and

Carmen Curutiu

submission deadline 20 Aug 2025 | 6 articles | Viewed by 8797 | Submission Open

Keywords: management of wounds; nanobiomaterials; infection control; chronic wounds; biofilm infections; wound dressings; tissue engineering; wound healing

(This special issue belongs to the Section Molecular Biology)

Breakthroughs in Diagnostic Prediction and Fundamental Therapeutics of Dementia and Movement Disorders, 2nd Edition

edited by

Yasemin M. Akay

submission deadline 20 Aug 2025 | 6 articles | Viewed by 8567 | Submission Open

Keywords: Parkinson's disease; dementia with Lewy bodies; Alzheimer's disease; pathogenic protein; biomarker; therapeutic target; drug

(This special issue belongs to the Section Molecular Neurobiology)

Bioceramics: Challenges and Medical Applications of Calcium-Phosphate-Based Biocompatible Ceramics

edited by

Kazuaki Hashimoto

and Mamoru Aizawa

submission deadline 20 Aug 2025 | 9 articles | Viewed by 8531 | Submission Open

Keywords: calcium phosphate synthesis; functional biomaterials; biological bone cements and adhesives; surface and interface properties; antibacterial and antiviral material; properties for medical applications; drug delivery properties; therapy and diagnostics; in vitro and in vivo evaluation

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Treatments of Organ Hypoxia or Ischemia

edited by

Athanasios Lourbopoulos

and

Iordanis Mourouzis

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8415 | Submission Open

Keywords: stroke; myocardial infarction; organ hypoxia; hypoxic molecular mechanisms; secondary hypoxia; inflammatory hypoxia; translational studies; diagnostic; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mast Cells in Immunity and Disease: Second Edition

edited by

Davide Firinu

Giovanni Paoletti

and

Giulia Costanzo

submission deadline 20 Aug 2025 | 5 articles | Viewed by 8392 | Submission Open

Keywords: mast-cell activation; secretion of MC-derived mediators; allergy; asthma; allergic rhinitis; urticaria; anaphylaxis; mastocytosis

(This special issue belongs to the Section Molecular Immunology)

Latest Advances in Reproduction Biology

edited by Clara Malo

submission deadline 20 Aug 2025 | 8 articles | Viewed by 8371 | Submission Open

Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology

(This special issue belongs to the Section Molecular Biology)

Stress Response Research: Yeast as Models: 2nd Edition

edited by

Cristina Mazzoni

and

Sergio Giannattasio

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8280 | Submission Open

Keywords: yeast; stress response; genetic disease; age-related disease; cell factory

(This special issue belongs to the Section Molecular Biology)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Basic Research to Clinical Approaches

edited by

Barbara Toffoli

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8251 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); steatosis; obesity; type 2 diabetes mellitus; therapeutic targets and interventions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional and Structural Genomics Studies for Plant Breeding

edited by

Andrea Cavallini

, Tommaso Giordani and Alberto Vangelisti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8223 | Submission Open

Keywords: plant transcriptomics; genome sequencing; plant gene function; molecular plant breeding; structural genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Biomolecular Basis of Life Processes

edited by

Janusz Błaszczyk

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8016 | Submission Open

Keywords: energy metabolism; bone-muscle interaction; ATP signalling; calcium– phosphate signalling; metabolic syndrome; aging; cellular turnover; cancers

(This special issue belongs to the Section Molecular Biology)

New Insights in Translational Bioinformatics: Second Edition

edited by

Camelia Quek

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7920 | Submission Open

Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology

(This special issue belongs to the Section Molecular Informatics)

Pathogenesis and Novel Therapeutic Approaches for Sarcomas

edited by Francisco Giner

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7912 | Submission Open

Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Function in Health and Diseases

edited by Sally P. Wheatley

submission deadline 20 Aug 2025 | 5 articles | Viewed by 7793 | Submission Open

Keywords: mitochondria; metabolism; lipid; ATP; respiration; calcium; iron; inheritance; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicity of Heavy Metal Compounds

edited by

Astrid Barkleit

submission deadline 20 Aug 2025 | 6 articles | Viewed by 7753 | Submission Open

Keywords: heavy metal; coordination; complexation; binding form; speciation; biomolecules; (cyto-) toxicity; cell death mechanism; spectroscopy; microscopy

(This special issue belongs to the Section Molecular Toxicology)

Advances and Challenges of Molecular Research on Disease in Animal Models in Biomedicine

edited by Minolfa C. Prieto

submission deadline 20 Aug 2025 | 5 articles | Viewed by 7644 | Submission Open

Keywords: animal models; cardiovascular disease; renal disease; metabolic; neurological; behavioral; and oncological disorders; pathophysiology; cell and molecular research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stress Tolerance and Genetic Diversity in Plants, 2nd Edition

edited by

Andrés J. Cortés

submission deadline 20 Aug 2025 | 6 articles | Viewed by 7518 | Submission Open

Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Signaling Molecules Involved in Gametes Development, Differentiation and Fertilization, 2nd Edition

edited by

Sergio Minucci

and

Massimo Venditti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7313 | Submission Open

Keywords: spermatogenesis; oogenesis; spermatozoa; oocyte; fertilization; acrosome reaction; fertility; epidydimal transit; endocrine disrupting chemicals; testicular and ovarian cancer

(This special issue belongs to the Section Molecular Biology)

Apolipoproteins and Lipoproteins in Health and Disease, 3rd Edition

edited by

Joan Carles Escolà-Gil

submission deadline 20 Aug 2025 | 5 articles | Viewed by 7312 | Submission Open

Keywords: apolipoproteins; Alzheimer's disease; atherosclerosis; cancer; cholesterol; diabetes; inflammation; obesity; lipid metabolism; lipoproteins

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Roles of Photodynamic Therapy in Tumors and Cancers

edited by Jianyong Liu

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7005 | Submission Open

Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer

(This special issue belongs to the Section Molecular Oncology)

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