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Calcium Metabolism and Regulation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 282

Special Issue Editors

E-Mail Website
Guest Editor
Department of Internal Medicine I, Nephrology, University Hospital Salzburg, Müllner Hauptstrasse 48, A-5020 Salzburg, Austria
Interests: nephrocalcinosis; nephrolithiasis; vascular calcification; calciphylaxis; calcifying skin disorders; vitamin D; parathyroid hormone; sodium thiosulfate; CKD-MBD; vitamin K2; myoinositol-hexaphosphate; oxidative stress

Special Issue Information

Dear Colleagues,

Calcium has multiple roles in biology, including cell signaling, motor function, and bone mineralization. Regulation of calcium homeostasis includes maintenance of normal blood levels, bone mineralization and inhibition of extraosseous depositions, neuronal and muscular function, intracellular compartmentation, shifting, and signaling. On a systemic level, this involves complex hormonal regulation of calcium and interconnected phosphate metabolism, prevention of mineral precipitation by a multi-factorial balance between promoters and inhibitors of calcification, and targeted transport mechanisms from soft tissues to bone structures. On a tissue level, local activation of specific proteins and enzymes may influence mineral deposition. On a cellular and subcellular level, it comprises regulation of calcium flux via ion channels and intracellular calcium shifts, as well as interaction with calcium-binding proteins for activation of further proteins and membrane functions. This Special Issue aims to give a scope of new developments in various areas of physiological and pathological calcium metabolism and regulation, including osteogenic transdifferentiation, the formation of pathological mineral depositions, and candidate molecules for the treatment of calcifying disorders.

So we would like to cordially invite you to contribute new scientific discoveries to this fascinating and multi-facetted field of research.

Dr. Hermann Salmhofer
Dr. Michael Lichtenauer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pathologic calcification
  • calcification inhibitors
  • calciprotein particles
  • Runx-2
  • apatite
  • matrix Gla protein
  • fetuin-A
  • vitamin D
  • parathyroid hormone

Published Papers

This special issue is now open for submission.
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