Calcium Metabolism and Regulation

Dear Colleagues,

Calcium has multiple roles in biology, including cell signaling, motor function, and bone mineralization. Regulation of calcium homeostasis includes maintenance of normal blood levels, bone mineralization and inhibition of extraosseous depositions, neuronal and muscular function, intracellular compartmentation, shifting, and signaling. On a systemic level, this involves complex hormonal regulation of calcium and interconnected phosphate metabolism, prevention of mineral precipitation by a multi-factorial balance between promoters and inhibitors of calcification, and targeted transport mechanisms from soft tissues to bone structures. On a tissue level, local activation of specific proteins and enzymes may influence mineral deposition. On a cellular and subcellular level, it comprises regulation of calcium flux via ion channels and intracellular calcium shifts, as well as interaction with calcium-binding proteins for activation of further proteins and membrane functions. This Special Issue aims to give a scope of new developments in various areas of physiological and pathological calcium metabolism and regulation, including osteogenic transdifferentiation, the formation of pathological mineral depositions, and candidate molecules for the treatment of calcifying disorders.

So we would like to cordially invite you to contribute new scientific discoveries to this fascinating and multi-facetted field of research.

Dr. Hermann Salmhofer
Guest Editor

Manuscript Submission Information

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