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The Wnt Signalling Pathway: A Tailored Target in Cancer

Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
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Int. J. Mol. Sci. 2020, 21(20), 7697; https://doi.org/10.3390/ijms21207697
Received: 29 September 2020 / Revised: 15 October 2020 / Accepted: 16 October 2020 / Published: 18 October 2020
(This article belongs to the Special Issue The Wnt Signaling Pathway in Cancer)
Cancer is one of the greatest public health challenges. According to the World Health Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most common cancers include lung, breast, colorectal, prostate, skin (non-melanoma) and stomach cancer. The unbalance of physiological signalling pathways due to the acquisition of mutations in tumour cells is considered the most common cancer driver. The Wingless-related integration site (Wnt)/β-catenin pathway is crucial for tissue development and homeostasis in all animal species and its dysregulation is one of the most relevant events linked to cancer development and dissemination. The canonical and the non-canonical Wnt/β-catenin pathways are known to control both physiological and pathological processes, including cancer. Herein, the impact of the Wnt/β-catenin cascade in driving cancers from different origin has been examined. Finally, based on the impact of Extracellular Vesicles (EVs) on tumour growth, invasion and chemoresistance, and their role as tumour diagnostic and prognostic tools, an overview of the current knowledge linking EVs to the Wnt/β-catenin pathway is also discussed. View Full-Text
Keywords: Wnt/β-catenin dependent pathway; Wnt/β-catenin independent pathway; colorectal cancer; breast cancer; ovarian cancer; extracellular vesicles Wnt/β-catenin dependent pathway; Wnt/β-catenin independent pathway; colorectal cancer; breast cancer; ovarian cancer; extracellular vesicles
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Koni, M.; Pinnarò, V.; Brizzi, M.F. The Wnt Signalling Pathway: A Tailored Target in Cancer. Int. J. Mol. Sci. 2020, 21, 7697.

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