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Article

Heterogeneous Disease Progression in a Mouse Model of Vascular Cognitive Impairment

by 1,2,3, 4, 4, 4, 5, 2,3,6 and 2,3,6,7,8,*
1
School of Medicine, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
2
Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
3
Samsung Alzheimer Research Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
4
Laboratory Animal Research Center, Samsung Biomedical Research Institute, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
5
Laboratory Animal Center, Osong Medical Innovation Foundation, Cheongju 28160, Korea
6
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
7
Neuroscience Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
8
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 2820; https://doi.org/10.3390/ijms21082820
Received: 10 March 2020 / Revised: 12 April 2020 / Accepted: 15 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Small Vessel Disease: A Whole Brain Disease)
Recently, an asymmetric vascular compromise approach that replicates many aspects of human vascular cognitive impairment (VCI) has been reported. The present study aimed to first investigate on the reproducibility in the disease progression of this newly reported VCI model using wild-type C57BL6/J mice. The second aim was to assess how this approach will affect the disease progression of transgenic Alzheimer’s disease (AD) 5XFAD mice subjected to VCI. C57BL6/J and 5XFAD mice were subjected to VCI by placing an ameroid constrictor on the right CCA and a microcoil on the left CCA. Infarcts and hippocampal neuronal loss did not appear predominantly in the right (ameroid side) as expected but randomly in both hemispheres. The mortality rate of C57BL6/J mice was unexpectedly high. Inducing VCI reduced amyloid burden in the hippocampi of 5XFAD mice. Since VCI is known to be complex and complicated, the heterogeneous disease progression observed from this current study shares close resemblance to the clinical manifestation of VCI. This heterogeneity, however, makes it challenging to test novel treatment options using this model. Further study is warranted to tackle the heterogeneous nature of VCI. View Full-Text
Keywords: vascular cognitive impairment; reproducibility; ameroid constrictor; microcoil; heterogeneity vascular cognitive impairment; reproducibility; ameroid constrictor; microcoil; heterogeneity
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MDPI and ACS Style

Lee, N.K.; Kim, H.; Yang, J.; Kim, J.; Son, J.P.; Jang, H.; Na, D.L. Heterogeneous Disease Progression in a Mouse Model of Vascular Cognitive Impairment. Int. J. Mol. Sci. 2020, 21, 2820. https://doi.org/10.3390/ijms21082820

AMA Style

Lee NK, Kim H, Yang J, Kim J, Son JP, Jang H, Na DL. Heterogeneous Disease Progression in a Mouse Model of Vascular Cognitive Impairment. International Journal of Molecular Sciences. 2020; 21(8):2820. https://doi.org/10.3390/ijms21082820

Chicago/Turabian Style

Lee, Na K., Hunnyun Kim, Jehoon Yang, Jeyun Kim, Jeong P. Son, Hyemin Jang, and Duk L. Na. 2020. "Heterogeneous Disease Progression in a Mouse Model of Vascular Cognitive Impairment" International Journal of Molecular Sciences 21, no. 8: 2820. https://doi.org/10.3390/ijms21082820

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