Special Issue "Redox Signaling and Oxidative Stress in Bone Health and Disease"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2020).
Interests: osteoclasts; osteoblasts; osteocytes; mitochondrial biogenesis; osteoporosis; aging; cellular senescence; oxidative stress
Balance between bone resorption and formation is essential to maintain bone homeostasis. However, physiological or pathological changes, such as aging or inflammation, can lead to both an increase in osteoclast and a decrease in osteoblast numbers, and eventually cause skeletal diseases. Thus, a better understanding the cellular and molecular mechanism(s) involved in the differentiation and activation of skeletal cells as well as chondrocytes is important for the development of novel therapies to treat skeletal diseases.
There is growing evidence that reactive oxygen species (ROS) play an important role in physiological intracellular signalling by triggering proliferation and survival in many different types of cells, including osteoclasts, osteoblasts, osteocytes, and chondrocytes. Mitochondrial oxidative phosphorylation produces ROS as by-products, which can be important signaling molecules but damage cells and contribute to disease and aging when they become excessive.
We invite researchers to submit original research and review articles covering significant developments in the mitochondrial function and oxidative stress of bone cells, as well as novel medicines or strategies that hold promise in the prevention and/or treatment of skeletal diseases. In particular, we welcome research covering novel molecular mechanism, new tools on bone research, or any animal studies with clinical relevance.
Dr. Ha-Neui Kim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- skeletal diseases