Quality Control of Mitochondria: Protection against Bone Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Role of Xenobiotics".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 2121
Special Issue Editor
Interests: osteoclasts; osteoblasts; osteocytes; mitochondrial quality control; osteoporosis; aging; cellular senescence; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A balance between the function of bone-resorbing osteoclasts and bone-building osteoblasts is essential for bone homeostasis. However, pathological or physiological changes, such as IRE, inflammation, or aging, lead to increased osteoclast numbers and decreased osteoblast numbers, tilting the balance in favor of bone resorption and eventually causing bone diseases. Thus, understanding the cellular and molecular mechanisms involved in the differentiation of the two types of bone cells is important for the development of novel therapies.
Mitochondria are dynamic organelles whose structure is constantly changing via several processes that include fusion and fission of the tubular mitochondrial network, mitochondrial biogenesis, and elimination of unwanted mitochondria by mitophagy (mitochondrial specific autophagy). Maintaining a healthy mitochondria network is vital for fatty acid oxidation, oxidative phosphorylation (OxPhos), and energy production, among many other metabolic functions. OxPhos produces mitochondrial ROS as byproducts, which can be important signaling molecules but, when produced in excess, damage cells and contribute to disease and aging.
We invite researchers to submit original research and review articles covering significant developments in the mitochondrial function and oxidative stress of bone cells, as well as novel medicines or strategies that hold promise in the prevention and/or treatment of skeletal diseases. In particular, we welcome research covering novel molecular mechanisms, new tools on bone research, or any animal studies with clinical relevance.
Dr. Ha-Neui Kim
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Osteoclast
- Osteoblast
- osteocyte
- chondrocyte
- ROS
- mitochondria
- skeletal diseases
- aging