Molecular Research in Renal Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 7384
Special Issue Editors
Interests: renal cell carcinoma; prostatic neoplasms; therapeutics
Special Issue Information
Dear Colleagues,
Renal tumors are grouped by the location in which they start growing and by their structure. There are several types of renal tumors: renal cell carcinoma (RCC), urothelial carcinoma, Wilms’ tumor, renal adenoma, and more.
RCC is the most common malignant kidney tumor, and it is dependent on angiogenesis. The most common aberrancy to occur in RCC is the inactivation of the Von Hippel Lindau (VHL) gene, which controls the constitutive activation of hipoxia-inducible factor (HIF)-mediated transcriptional pathways. This process provides greater vasculature and survivability to the tumor by increasing anti-vascular endothelial growth factor (VEGF) transcription.
By studying the role of angiogenesis and immunity in the pathogenesis of RCC, we find that an upfront combination of different immune checkpoint inhibitors, and the combination of immunotherapy with targeted agents significantly improve outcomes of treatment-naïve advanced RCC patients.
However, a proportion of patients present primary resistance or develop a secondary resistance to such therapy. In these cases, working on the inhibition of alternative pathways such as PI3K/Akt/mTOR or the glutamine pathway can represent a tool to overcome resistance to therapy. From this perspective, finding predictive molecular factors and understanding the tumor biology in pre-treated advanced RCC become crucial in order to find new strategies to overcome resistance. We aim to review the literature for different pathways that could potentially play a role in advanced RCC treatment which has progressed to first-line therapy.
This Special Issue on "Molecular Research in Renal tumors" aims to develop an updated picture of renal tumors (especially for renal cell carcinoma), focusing on molecular biomarkers, the multimodal treatment of locally advanced and metastatic disease, systemic therapy, and rare histology.
Prof. Dr. Giuseppe Procopio
Dr. Pierangela Sepe
Guest Editors
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Keywords
- renal tumor
- kidney cancer
- advanced renal cell carcinoma
- combination therapy
- resistance
- metabolism
- antiangiogenic drugs
- tyrosine-kinase inhibitors
- immunotherapy