Recombinant Proteins

Dear Colleagues,

By simple definition, a recombinant protein is a protein encoded by a heterologous or synthetic gene(s)—recombinant DNA—that has been cloned in a system that supports expression of the gene(s) to produce messenger RNA (mRNA) followed by translation to protein and possibly post-translational modification and subcellular targeting. Modification of the gene by recombinant DNA technology can lead to expression of many proteins. Potential applications of these recombinant protein products include human and animal therapeutics, subunit vaccines, diagnostics, industrial enzymes, food additives or processing agents, crop protectant biologics, biopolymers, and reagents, to name a few. Although there are a variety of potential hosts and manufacturing strategies that are currently available or are being developed, each application has different constraints in terms of capital and manufacturing cost, production scale needed, quality and purity attributes, and regulatory requirements.

The focus of this Special Issue of the International Journal of Molecular Sciences (IJMS), entitled Recombinant Proteins, is the science and engineering of recombinant protein production, particularly production of complex and hard to produce proteins (membrane proteins, ones with solubility issues or requiring extensive post-translational modifications), transient production of recombinant proteins in a variety of hosts for rapid response, novel expression systems, host engineering and stability, secretion, localization and post-translational modifications, protein engineering including enzyme engineering, fusion proteins and biobetter biologics.

Prof. Karen A. McDonald
Prof. Somen Nandi
Guest Editors

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