Special Issue "Recombinant Proteins"
Deadline for manuscript submissions: closed (30 November 2017).
By simple definition, a recombinant protein is a protein encoded by a heterologous or synthetic gene(s)—recombinant DNA—that has been cloned in a system that supports expression of the gene(s) to produce messenger RNA (mRNA) followed by translation to protein and possibly post-translational modification and subcellular targeting. Modification of the gene by recombinant DNA technology can lead to expression of many proteins. Potential applications of these recombinant protein products include human and animal therapeutics, subunit vaccines, diagnostics, industrial enzymes, food additives or processing agents, crop protectant biologics, biopolymers, and reagents, to name a few. Although there are a variety of potential hosts and manufacturing strategies that are currently available or are being developed, each application has different constraints in terms of capital and manufacturing cost, production scale needed, quality and purity attributes, and regulatory requirements.
The focus of this Special Issue of the International Journal of Molecular Sciences (IJMS), entitled Recombinant Proteins, is the science and engineering of recombinant protein production, particularly production of complex and hard to produce proteins (membrane proteins, ones with solubility issues or requiring extensive post-translational modifications), transient production of recombinant proteins in a variety of hosts for rapid response, novel expression systems, host engineering and stability, secretion, localization and post-translational modifications, protein engineering including enzyme engineering, fusion proteins and biobetter biologics.
Prof. Karen A. McDonald
Prof. Somen Nandi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Recombinant Proteins
- Recombinant DNA
- Rapid (e.g., transient) production
- Scale-up of production platforms
- New hosts for rapid production
- Novel technologies to treat or prevent pathogens