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Int. J. Mol. Sci. 2018, 19(1), 177; https://doi.org/10.3390/ijms19010177

Fusion Proteins of NKG2D/NKG2DL in Cancer Immunotherapy

Department of Biological Sciences, Clemson University, 190 Collings Street, Clemson, SC 29634, USA
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Received: 30 November 2017 / Revised: 22 December 2017 / Accepted: 3 January 2018 / Published: 7 January 2018
(This article belongs to the Special Issue Recombinant Proteins)
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Abstract

NKG2D (natural killer group 2, member D) is an important activating receptor in natural killer (NK) cells and some T cells. NKG2D ligands (NKG2DLs) are specifically expressed on most tumor cells. The engagement of these ligands on tumor cells to NKG2D on NK cells will induce cell-mediated cytotoxicity and have target cells destroyed. This gives NKG2D/NKG2DLs great potential in cancer therapeutic application. The creation of NKG2D/NKG2DL-based multi-functional fusion proteins is becoming one of the most promising strategies in immunotherapy for cancer. Antibodies, cytokines, and death receptors have been fused with NKG2D or its ligands to produce many powerful fusion proteins, including NKG2D-based chimeric antigen receptors (CARs). In this article, we review the recent developments of the fusion proteins with NKG2D/NKG2DL ligands in cancer immunotherapy. View Full-Text
Keywords: fusion protein; NKG2D; NKG2D ligands; NKG2D CARs; cancer immunotherapy fusion protein; NKG2D; NKG2D ligands; NKG2D CARs; cancer immunotherapy
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Ding, H.; Yang, X.; Wei, Y. Fusion Proteins of NKG2D/NKG2DL in Cancer Immunotherapy. Int. J. Mol. Sci. 2018, 19, 177.

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