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NADPH Oxidases and Mitochondria in Vascular Senescence

Department of Nutrition, Food and Exercise Sciences and Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), Florida State University, Tallahassee, FL 32306, USA
Int. J. Mol. Sci. 2018, 19(5), 1327; https://doi.org/10.3390/ijms19051327
Received: 31 March 2018 / Revised: 22 April 2018 / Accepted: 27 April 2018 / Published: 29 April 2018
(This article belongs to the Special Issue Free Radicals and Oxidants in Pathogenesis)
Aging is the major risk factor in the development of cardiovascular diseases (CVDs), including hypertension, atherosclerosis, and myocardial infarction. Oxidative stress caused by overproduction of reactive oxygen species (ROS) and/or by reduced expression of antioxidant enzymes is a major contributor to the progression of vascular senescence, pathologic remodeling of the vascular wall, and disease. Both oxidative stress and inflammation promote the development of senescence, a process by which cells stop proliferating and become dysfunctional. This review focuses on the role of the mitochondria and the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases Nox1 and Nox4 in vascular senescence, and their contribution to the development of atherosclerosis. Recent findings are reviewed, supporting a critical role of the mitochondrial regulator peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1α (PGC-1α), the inflammatory gene nuclear factor κB (NF-κB), zinc, the zinc transporters (ZnTs) ZnT3 and ZnT10, and angiotensin II (Ang II) in mitochondrial function, and their role in telomere stability, which provides new mechanistic insights into a previously proposed unified theory of aging. View Full-Text
Keywords: senescence; Nox1; Nox4; mitochondria; NF-κB; VSMCs; SASP; zinc; ZnT3; ZnT10 senescence; Nox1; Nox4; mitochondria; NF-κB; VSMCs; SASP; zinc; ZnT3; ZnT10
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MDPI and ACS Style

Salazar, G. NADPH Oxidases and Mitochondria in Vascular Senescence. Int. J. Mol. Sci. 2018, 19, 1327. https://doi.org/10.3390/ijms19051327

AMA Style

Salazar G. NADPH Oxidases and Mitochondria in Vascular Senescence. International Journal of Molecular Sciences. 2018; 19(5):1327. https://doi.org/10.3390/ijms19051327

Chicago/Turabian Style

Salazar, Gloria. 2018. "NADPH Oxidases and Mitochondria in Vascular Senescence" International Journal of Molecular Sciences 19, no. 5: 1327. https://doi.org/10.3390/ijms19051327

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