Special Issue "Molecular Aspects of Inflammation in Pregnancy"
Deadline for manuscript submissions: closed (10 November 2019) | Viewed by 18542
Interests: placenta development; trophoblast differentiation; cytokines and chemokines in placenta physiology; maternal–fetal cross-talk
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Uncomplicated human pregnancy relies on a fine-balanced synergistic cross-talk of inflammatory and immune-modulating factors. Hence, maternal immune functions need to adapt to different stages of pregnancy, which are characterized by unique inflammatory environments. Unrestrained, exaggerated inflammation in human pregnancy is directly associated with increased mortality and morbidity of the mother and offspring. The major complications of pregnancy, including pre-eclampsia, fetal growth restriction, gestational diabetes and/or obesity ("diabesity"), preterm labor, and miscarriage have been associated with an abnormal maternal inflammatory response, both systemically and locally at the placenta. Although much progress is being made in understanding the molecular basis of these disorders, a significant knowledge gap still exists, in identifying important molecular targets and pathways, which could eventually contribute to the development of new drug therapies and the improvement of pregnancy outcomes.
This Special Issue, "Molecular Aspects of Inflammation in Pregnancy", will cover a selection of recent research topics and current review articles related to molecular mechanisms, leading to abberant inflammatory processes in human pregnancy complications. Experimental papers, up-to-date review articles, and commentaries are all welcome.
Prof. Martin Gauster
Manuscript Submission Information
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- Fetal growth restriction
- Gestational diabetes
- Gestational hypertension
- Preterm labor