Special Issue "Inflammation in Pregnancy"

A special issue of Reproductive Medicine (ISSN 2673-3897).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2165

Special Issue Editor

Dr. Martin Gauster
E-Mail Website
Guest Editor
Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstraße 6/II, 8010 Graz, Austria
Interests: placenta development; trophoblast differentiation; cytokines and chemokines in placenta physiology; maternal–fetal cross-talk
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Special Issue Information

Dear Colleagues,

Uncomplicated human pregnancy relies on the finely balanced synergistic crosstalk of inflammatory and immune-modulating factors. Hence, maternal immune functions need to adapt to different stages of pregnancy, which are characterized by unique inflammatory environments. Unrestrained and exaggerated inflammation in human pregnancy is directly associated with the increased mortality and morbidity of the mother and offspring. The major complications of pregnancy, including pre-eclampsia, fetal growth restriction, gestational diabetes and/or obesity (“diabesity”), preterm labor, and miscarriage, are associated with an abnormal maternal inflammatory response, both systemically and locally at the placenta.

Although much progress is being made in understanding the molecular basis of these disorders, a significant knowledge gap still exists in identifying important molecular targets and pathways, which could eventually contribute to the development of new drug therapies and the improvement of pregnancy outcomes.

This Special Issue, “Inflammation in Pregnancy”, will cover a selection of recent research topics and current review articles related to the molecular mechanisms leading to aberrant inflammatory processes in human pregnancy complications. Experimental papers, up-to-date review articles, and commentaries are all welcome.

Dr. Martin Gauster
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reproductive Medicine is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy
  • inflammation
  • placenta
  • pre-eclampsia
  • fetal growth restriction
  • gestational diabetes
  • gestational hypertension
  • preterm labor

Published Papers (1 paper)

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Systematic Review
Inflammation and Preterm Birth: A Systematic Review
Reprod. Med. 2022, 3(2), 101-111; https://doi.org/10.3390/reprodmed3020009 - 01 May 2022
Cited by 4 | Viewed by 1573
Abstract
Inflammatory mechanisms have a critical role in parturition, which results from a gathering of different stimuli that collectively initiate labour. In fact, a sophisticated interaction occurs between contractile and immuno-inflammatory pathways, whereby proinflammatory amplification is intensified by collaborative connections between cells, ligands, and [...] Read more.
Inflammatory mechanisms have a critical role in parturition, which results from a gathering of different stimuli that collectively initiate labour. In fact, a sophisticated interaction occurs between contractile and immuno-inflammatory pathways, whereby proinflammatory amplification is intensified by collaborative connections between cells, ligands, and tissues. Preterm birth (PTB) is one of the major challenges of modern obstetrics and still lacks an efficient treatment. Therefore, the scientific research of modern therapies is warranted. This systematic review aims to provide an overview of recent research into inflammation and PTB. The main inclusion criterion was articles concerning birth and inflammation, and searches were performed in the electronic databases MEDLINE, Embase, Scopus, Web of Science and Cochrane Library, from 2017 to 2021. A literature search from all databases yielded 1989 results which, applying the specified eligibility criteria, resulted in the 16 articles included in this review. Delivery is the consequence of an inequity between maternal inflammation and hormonal-driven uterine quiescence. Studies show that the distinction between term and preterm labour could consist of a pre-existing disproportion of decidual inflammatory signalling, or an unusual stimulus eliciting inflammatory pathways, comparable to both. Thus, controlling inflammation could be hopeful for detaining PTB. Full article
(This article belongs to the Special Issue Inflammation in Pregnancy)
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