ijms-logo

Journal Browser

Journal Browser

Special Issue "Oral Squamous Cell Carcinoma"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 August 2020.

Special Issue Editor

Prof. Tadaaki Kirita
Website
Guest Editor
Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Schijo-cho, Nara-Kashihara 634-8521, Japan
Interests: Oral cancer; Biomarkers; Molecular biology; Cancer genetics; Reconstructive surgery; Chemotherapy; Treatment of advanced oral cancer

Special Issue Information

Dear Colleagues,

Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth most common cancer worldwide. It is accepted that OSCC arises from multiple genetic alterations caused by chronic exposure to carcinogens such as alcohol, smoking, viral infections, and inflammation. These genetic alterations, which include deletions, point mutations, promoter methylation, and gene amplification of oncogenes, inactivate tumor suppressor genes. The molecular mechanisms of carcinogenesis, tumor progression, and metastasis of oral cancer have been elucidated by recent advances in molecular biology. However, many unsolved questions still remain.

This Special Issue on “Oral Squamous Cell Carcinoma” has the objective of developing an updated investigation and rationale of biological behavior of oral squamous cell carcinoma focusing on molecular biology, pathology, biomarkers, genetics, diagnostics, and therapeutics.

Prof. Tadaaki Kirita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Oral squamous cell carcinoma
  • Molecular biology
  • Pathology
  • Biomarkers
  • Genetic mutation
  • Biological behavior
  • Diagnostics and therapeutics

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessArticle
Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma
Int. J. Mol. Sci. 2020, 21(10), 3655; https://doi.org/10.3390/ijms21103655 - 22 May 2020
Abstract
Because oral squamous cell carcinomas (OSCCs) have a high potential for locoregional invasion and nodal metastasis, early detection and treatment are essential. A LAP2, emerin, MAN1 (LEM) domain containing 1 (LEMD1) is associated with local progression, clinical stage, nodal metastasis, poor prognosis, angiogenesis, [...] Read more.
Because oral squamous cell carcinomas (OSCCs) have a high potential for locoregional invasion and nodal metastasis, early detection and treatment are essential. A LAP2, emerin, MAN1 (LEM) domain containing 1 (LEMD1) is associated with local progression, clinical stage, nodal metastasis, poor prognosis, angiogenesis, and lymphangiogenesis in OSCC. Although LEMD is a cancer-testis antigen, the cancer-related signals related to LEMD1 remain unknown. In this study, we used a microarray analysis of OSCC cells to identify sushi repeat containing protein X-linked 2 (SRPX2) as a LEMD1-related downstream signal. LEMD1 expression was correlated with lymph node metastasis of OSCC according to the immunohistochemistry analysis. Furthermore, patients expressing SRPX2 had a significantly worse prognosis than those without SRPX2 expression. The concentration of SRPX2 in OSCC was positively correlated with the concentrations of LEMD1, urokinase plasminogen activator receptor (uPAR), and hepatocyte growth factor (HGF). In OSCC cells, SRPX2 secretion levels were elevated by interactions with uPAR and HGF. We also found that SRPX2 promotes endothelial cell proliferation and adhesion between endothelial cells and OSCC cells. These results suggest that SRPX2 might be a useful tumor marker for OSCC. Full article
(This article belongs to the Special Issue Oral Squamous Cell Carcinoma)
Show Figures

Figure 1

Back to TopTop