Molecular Research on Obstetrics and Gynecology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 21256
Special Issue Editors
Interests: endometriosis; endometrial pathology; minimally invasive surgery
Special Issues, Collections and Topics in MDPI journals
Interests: endometriosis; endometrial pathology; minimally invasive surgery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Our knowledge relating to the theoretical and clinical aspects in the field of medicine has increased exponentially in recent years.
Benign (including endometrial pathology, uterine fibroids, endometriosis, and ovarian disorders) and malignant (including endometrial, cervical, and ovarian cancer) gynecological pathologies represent, respectively, the most common and most harmful diseases affecting women’s health.
The molecular approach to gynecology is, therefore, an interesting option to understand cellular mechanisms and hormonal pathways in order to diagnose early and better treat these pathologies.
This Special Issue is focused on publishing outstanding research in molecular, precision-based approaches that may open up new fields and bring forth new points of view.
Regarding cervical cancer, diagnostic techniques for human papillomavirus detection and genotyping represents an intriguing option in order to detect the high-risk strains and amplify fragments of DNA from a targeted gene sequence. In endometrial cancer, a molecular approach involving the TCGA (The Cancer Genome Atlas) group, microsatellite instability molecular testing, as well as copy-number-low/p53-wild-type (p53wt), POLE-mutated/ultramutated (POLEmt) are crucial for understanding the prognostic value of the neoplasm and choosing the appropriate surgical and clinical management.
New evidence is showing a promising role of micro-RNAs as potential biomarkers for endometriosis and for the pathophysiology of uterine fibroids, unravelling new pathogenetic and therapeutic pathways. For this reason, a molecular, precision-based approach is undoubtfully important also in benign gynecological diseases.
To date, several issues have arisen around the technical elements of molecular biomarkers, and therapies and have not yet fulfilled their expectations. Concerning benign and malignant gynecology, new molecular discoveries are influenced by technical issues such as test sensitivity and genetic heterogeneity. As molecular medicine becomes a more integral part of routine medical practice, it is fundamental that healthcare providers be aware of advances in the understanding of how several benign and malignant gynecological diseases can benefit from a precision-based approach, in order to improve the efficacy and impact of the standard of care, affecting women’s health and wellbeing.
This collection will not be limited to clinical work about diagnosis, or clinical and surgical managements, but it will specifically involve basic science (immunobiology, cellular and molecular biology, genetics, and epigenetics), to deepen the actual knowledge and discover new fields for the future diagnosis and treatment of uterine and cervical pathologies, endometriosis, ovarian diseases, as well as the precision-based approach to infertility and gynecological malignancies.
Dr. Pasquale De Franciscis
Dr. Gaetano Riemma
Guest Editors
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Keywords
- Precision medicine
- Cancer immunology
- Biomarkers
- Infertility
- Minimally invasive gynecology
- Molecular testing
- Endometrial cancer
- Ovarian cancer
- Cervical cancer
- Ovarian neoplasms
- Endometriosis
- Uterine fibroids
- Epigenetics
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