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Special Issue "Preventive and Therapeutic Nutraceuticals against Chronic Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 15 April 2021.

Special Issue Editors

Prof. Dr. Luis Cisneros-Zevallos
Guest Editor
Department of Horticultural Sciences, Texas A&M University, College Station, TX 77843-2133, USA
Interests: secondary metabolism of plants under stress conditions; functional foods and cell molecular targets; postharvest biology and technology
Special Issues and Collections in MDPI journals
Prof. Dr. Daniel Jacobo-Velazquez
Website SciProfiles
Guest Editor
Centro de Biotecnología-FEMSA, School of Engineering and Sciences. Tecnológico de Monterrey. E. Garza Sada 2501 Sur, C.P. 64849, Monterrey, N.L., Mexico
Interests: phenolics biosynthesis; methods of analysis; antioxidant activity; non-thermal processing technologies; extraction and purification techniques; postharvest physiology; postharvest stress responses
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, "Preventive and Therapeutic Nutraceuticals against Chronic Diseases", will cover a selection of recent research topics and current review articles in the field of nutraceuticals, focusing on in vitro, in vivo, and clinical studies evaluating their potential application as preventive and therapeutic agents against chronic disease. Experimental papers, up-to-date review articles, and commentaries are all welcome.

Today, chronic diseases are the leading causes of death worldwide, including cancer, diabetes, cardiovascular (ischemic heart disease, stroke), respiratory (chronic obstructive pulmonary disease), and neurological disorders (Alzheimer’s disease and other dementias). Two main approaches have been used to combat chronic diseases: prevention and treatment. Some treatments exist that ease symptoms and can sometimes cure chronic diseases if diagnosed early but are very expensive and may have adverse side effects. Developing a new drug is highly costly. Thus, researchers have been increasingly investigating a group of compounds naturally found in foods, known as nutraceuticals, for the management of chronic diseases. Nutraceuticals possess many attractive advantages; they are natural, safe for consumption, less expensive than drugs, and have preventive and therapeutic activities against chronic diseases. Hence, nutraceuticals have potential as alternative treatments for CDDs.

There are three states linked to developing a chronic disease as indicated in the following figure: the healthy, pre-disease, and disease states. The pre-disease state is a condition where an individual presents certain symptoms that if not attended might develop into disease (e.g., high level of glucose in the blood might lead to diabetes; polyps in the colon might develop into colon cancer). In this Special Issue, we would like to receive contributions that add information about specific nutraceuticals that can reverse the pre-disease state to the healthy state and the disease state to the pre-disease state. Studies evaluating nutraceuticals by in vitro, in vivo and clinical studies are welcome.

Prof. Dr. Luis Cisneros-Zevallos
Prof. Dr. Daniel Jacobo-Velazquez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nutraceuticals
  • Chronic diseases
  • In vitro studies
  • In vivo studies
  • Clinical studies
  • Preventive effect
  • Therapeutic effect

Published Papers (1 paper)

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Open AccessArticle
Goat’s Milk Intake Prevents Obesity, Hepatic Steatosis and Insulin Resistance in Mice Fed A High-Fat Diet by Reducing Inflammatory Markers and Increasing Energy Expenditure and Mitochondrial Content in Skeletal Muscle
Int. J. Mol. Sci. 2020, 21(15), 5530; https://doi.org/10.3390/ijms21155530 - 01 Aug 2020
Goat’s milk is a rich source of bioactive compounds (peptides, conjugated linoleic acid, short chain fatty acids, monounsaturated and polyunsaturated fatty acids, polyphenols such as phytoestrogens and minerals among others) that exert important health benefits. However, goat’s milk composition depends on the type [...] Read more.
Goat’s milk is a rich source of bioactive compounds (peptides, conjugated linoleic acid, short chain fatty acids, monounsaturated and polyunsaturated fatty acids, polyphenols such as phytoestrogens and minerals among others) that exert important health benefits. However, goat’s milk composition depends on the type of food provided to the animal and thus, the abundance of bioactive compounds in milk depends on the dietary sources of the goat feed. The metabolic impact of goat milk rich in bioactive compounds during metabolic challenges such as a high-fat (HF) diet has not been explored. Thus, we evaluated the effect of milk from goats fed a conventional diet, a conventional diet supplemented with 30% Acacia farnesiana (AF) pods or grazing on metabolic alterations in mice fed a HF diet. Interestingly, the incorporation of goat’s milk in the diet decreased body weight and body fat mass, improved glucose tolerance, prevented adipose tissue hypertrophy and hepatic steatosis in mice fed a HF diet. These effects were associated with an increase in energy expenditure, augmented oxidative fibers in skeletal muscle, and reduced inflammatory markers. Consequently, goat’s milk can be considered a non-pharmacologic strategy to improve the metabolic alterations induced by a HF diet. Using the body surface area normalization method gave a conversion equivalent daily human intake dose of 1.4 to 2.8 glasses (250 mL per glass/day) of fresh goat milk for an adult of 60 kg, which can be used as reference for future clinical studies. Full article
(This article belongs to the Special Issue Preventive and Therapeutic Nutraceuticals against Chronic Diseases)
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