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Special Issue "Nuclear Lipid Signaling"
Deadline for manuscript submissions: closed (31 March 2019).
Interests: osteosarcoma, signal transduction, nucleus, phosphoinositide signaling, cyclin D3, Akt, chemotherapeutic agents, differentiation, nuclear phosphoinositides
For the last 20 years, a large number of papers have hinted at the existence and significance of signaling events inside the nucleus, mediated by lipids and lipid metabolism. This signaling involves PLCs, DGKs, PLD, sphingolipid-related enzymes. Interestingly, alterations of the signaling machinery have been detected in a number of diseases and this opens an entirely new field of investigation. Even though a large amount of data is related to inositol lipid and inositide-related signaling, clear evidence show that DGKs play important role in nuclear function, sphingolipid metabolites are active in the nucleus and inositol phosphates are important in RNA export. Recently, it has been shown that nuclear translocation of PKCα isoenzyme is involved in neurogenic commitment of human neural crest-derived periodontal ligament stem cells.
These evidences prompted us to edit a comprehensive, as much as possible, special issue dealing with the signaling machineries that have been found and studied at the nuclear level.
In this context, we would like to invite review and original articles that focus on nuclear structure, presence of lipids in sunclear domains, lipid mediated signaling in both normal and pathological conditions. Additionally, articles showing how phospholipids in general and polyohosphoinositide in particular and/or their metabolizing enzymes directly affects the transcriptional machinery are welcome. Given that a particular interest has been raised by the fact that inositide and inositide-related nuclear signaling (i.e., PKCs translocation into the nucleus) play a role during growth and differentiation of progenitor/stem cells, manuscripts dealing with nuclear lipid signaling in progenitor/stem cells are welcome as well.
Dr. Irene Faenza
Manuscript Submission Information
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