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Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage

1
National Institute of Molecular Genetics (INGM), 20122 Milan, Italy
2
The FIRC Institute of Molecular Oncology (IFOM), 20139 Milan, Italy
3
School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK
4
Department of Biomedical e Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2080; https://doi.org/10.3390/ijms20092080
Received: 31 March 2019 / Revised: 20 April 2019 / Accepted: 23 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue Nuclear Lipid Signaling)
Phosphatidylinositol (PI)-related signaling plays a pivotal role in many cellular aspects, including survival, cell proliferation, differentiation, DNA damage, and trafficking. PI is the core of a network of proteins represented by kinases, phosphatases, and lipases which are able to add, remove or hydrolyze PI, leading to different phosphoinositide products. Among the seven known phosphoinositides, phosphatidylinositol 5 phosphate (PI5P) was the last to be discovered. PI5P presence in cells is very low compared to other PIs. However, much evidence collected throughout the years has described the role of this mono-phosphoinositide in cell cycles, stress response, T-cell activation, and chromatin remodeling. Interestingly, PI5P has been found in different cellular compartments, including the nucleus. Here, we will review the nuclear role of PI5P, describing how it is synthesized and regulated, and how changes in the levels of this rare phosphoinositide can lead to different nuclear outputs. View Full-Text
Keywords: PI5P; PIKFyve; myotubularin; PI5P4K/PIP4K; phosphatases; nucleus PI5P; PIKFyve; myotubularin; PI5P4K/PIP4K; phosphatases; nucleus
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Poli, A.; Zaurito, A.E.; Abdul-Hamid, S.; Fiume, R.; Faenza, I.; Divecha, N. Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage. Int. J. Mol. Sci. 2019, 20, 2080.

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