Next Article in Journal
Rottlerin Reduces cAMP/CREB-Mediated Melanogenesis via Regulation of Autophagy
Next Article in Special Issue
Nuclear Phosphoinositides: Their Regulation and Roles in Nuclear Functions
Previous Article in Journal
Development-Related miRNA Expression and Target Regulation during Staggered In Vitro Plant Regeneration of Tuxpeño VS-535 Maize Cultivar
Previous Article in Special Issue
Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments
Open AccessReview

Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage

National Institute of Molecular Genetics (INGM), 20122 Milan, Italy
The FIRC Institute of Molecular Oncology (IFOM), 20139 Milan, Italy
School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK
Department of Biomedical e Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, Italy
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2080;
Received: 31 March 2019 / Revised: 20 April 2019 / Accepted: 23 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue Nuclear Lipid Signaling)
Phosphatidylinositol (PI)-related signaling plays a pivotal role in many cellular aspects, including survival, cell proliferation, differentiation, DNA damage, and trafficking. PI is the core of a network of proteins represented by kinases, phosphatases, and lipases which are able to add, remove or hydrolyze PI, leading to different phosphoinositide products. Among the seven known phosphoinositides, phosphatidylinositol 5 phosphate (PI5P) was the last to be discovered. PI5P presence in cells is very low compared to other PIs. However, much evidence collected throughout the years has described the role of this mono-phosphoinositide in cell cycles, stress response, T-cell activation, and chromatin remodeling. Interestingly, PI5P has been found in different cellular compartments, including the nucleus. Here, we will review the nuclear role of PI5P, describing how it is synthesized and regulated, and how changes in the levels of this rare phosphoinositide can lead to different nuclear outputs. View Full-Text
Keywords: PI5P; PIKFyve; myotubularin; PI5P4K/PIP4K; phosphatases; nucleus PI5P; PIKFyve; myotubularin; PI5P4K/PIP4K; phosphatases; nucleus
Show Figures

Graphical abstract

MDPI and ACS Style

Poli, A.; Zaurito, A.E.; Abdul-Hamid, S.; Fiume, R.; Faenza, I.; Divecha, N. Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage. Int. J. Mol. Sci. 2019, 20, 2080.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop