Regulation of Skeletal Muscle Function by Means of Nutraceuticals, Hormones and Physical Activity
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Sports Nutrition".
Deadline for manuscript submissions: closed (25 January 2025) | Viewed by 1061
Special Issue Editors
Interests: muscle atrophy; apoptosis; autophagy; oxidative stress; cancer cells; morphological and molecular analyses
Special Issues, Collections and Topics in MDPI journals
Interests: osteosarcoma; myotonic dystrophy; signal transduction; phosphoinositide signaling; cyclin D3; Akt; chemotherapeutic agents; differentiation; nuclear phosphoinositides agents; differentiation; nuclear phosphoinositides
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The primary function of skeletal muscles is to maintain metabolic health and physical performance. Muscular dystrophies and aging-related sarcopenia are skeletal muscle disorders characterized by muscle mass decline, strength and balance impairment, and a reduction in motility, leading to frailty and increasing the risk of hospitalization. Furthermore, catabolic conditions, including cancer, infections, diabetes, organ failure, and inactivity/disuse, cause a net loss of proteins, organelles, and cytoplasm, which, in turn, leads to muscle wasting. Several pieces of evidence show that nutrition, hormones, and physical exercise interventions can regulate complex pathological and physiological mechanisms, including oxidative stress, inflammation, apoptosis, cytokine release, protein synthesis, and satellite cell activity. The modulation of all these signaling pathways converges on a balanced protein and organelle turnover, critical for maintaining skeletal muscle function. However, studies on muscle function preservation are still limited and need further exploration due to the lack of efficient treatments capable of counteracting muscle loss and damage. This Special Issue would like to collect original papers and reviews with the aim to understand novel insights on nutraceutical, hormone, or physical activity supplementation as potential strategies (also in synergy) for the prevention of muscle dysfunctions.
Dr. Sara Salucci
Dr. Irene Faenza
Guest Editors
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Keywords
- skeletal muscle dysfunctions
- muscle atrophy
- muscle disorders
- oxidative stress
- cell death
- muscle cellular mechanisms
- protein synthesis/proteolysis
- natural compounds
- diet
- hormones
- physical activity
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