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Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy
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Authors to whom correspondence should be addressed.
The authors contributed equally to the manuscript.
Int. J. Mol. Sci. 2019, 20(8), 2026; https://doi.org/10.3390/ijms20082026
Received: 25 March 2019 / Revised: 19 April 2019 / Accepted: 21 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Nuclear Lipid Signaling)
Stem cells are undifferentiated cells that can give rise to several different cell types and can self-renew. Given their ability to differentiate into different lineages, stem cells retain huge therapeutic potential for regenerative medicine. Therefore, the understanding of the signaling pathways involved in stem cell pluripotency maintenance and differentiation has a paramount importance in order to understand these biological processes and to develop therapeutic strategies. In this review, we focus on phosphoinositide 3 kinase (PI3K) since its signaling pathway regulates many cellular processes, such as cell growth, proliferation, survival, and cellular transformation. Precisely, in human stem cells, the PI3K cascade is involved in different processes from pluripotency and induced pluripotent stem cell (iPSC) reprogramming to mesenchymal and oral mesenchymal differentiation, through different and interconnected mechanisms. View Full-Text
Keywords: stem cells; nucleus; inositide signaling stem cells; nucleus; inositide signaling
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Ramazzotti, G.; Ratti, S.; Fiume, R.; Follo, M.Y.; Billi, A.M.; Rusciano, I.; Owusu Obeng, E.; Manzoli, L.; Cocco, L.; Faenza, I. Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments. Int. J. Mol. Sci. 2019, 20, 2026.

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