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Nanomaterials for Theranostics and Tissue Engineering Applications

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 9550

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Special Issue Editor

Dr. Mario Ledda

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Guest Editor

CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy
Interests: regenerative medicine; tissue engineering; nanomedicine; biotechnology; biomaterials; stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, nanomaterials are emerging as promising agents for both therapeutic and diagnostic (theranostic) applications, and also for their possible use in tissue engineering and regenerative medicine. Research efforts are moving towards the exploration of new materials that can foster the clinical translation of biotechnological approaches aimed at non-invasive imaging, biomarker development and drug targeting. Many types of nanomaterials, including nanoparticles, quantum dots and nanostructures, have shown both diagnostic and therapeutic potential that strongly depend on size control and surface modification. These aspects can influence biocompatibility and interactions with biological systems. A key element for research on theranostic agents in the near future is the need to improve disease detection and therapeutic efficacy.

This Special Issue on “Nanomaterials for Theranostics and tissue Engineering Applications” welcomes original research and reviews in nanomedicine and nanotechnology field, with a focus on all aspects of design, characterization, evaluation, and development of novel nanomaterial and nanotechnology for medicine applications and the challenges of their use, both from a diagnostic and a therapeutic point of view.

We would like to focus on the following concepts:

Study, design, characterization and development of biosensors and theragnostic platforms based on advanced nanostructured systems.
New intelligent biomaterials and nano-structured devices, functionalized metal nanoparticles and polymeric devices for imaging, tissue engineering, organ on chip, stem cell therapy and drug delivery;

Acoustic, optical and electrical nano-biosensors and advanced microfluidic devices and lab-on-chip for bioanalytics, diagnostics, drug testing and drug discovery

Dr. Mario Ledda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanomaterial
nanotechnology
intelligent biomaterials
drug testing
drug discovery
drug delivery
theragnostic platforms
biosensing
tissue engineering

Published Papers (3 papers)

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Research

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15 pages, 28358 KiB

Open AccessArticle

MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System

by Marina Paiva Abuçafy, Regina Celia Galvao Frem, Giulia Polinario, Fernando Rogerio Pavan, Heng Zhao, Angelika Mielcarek, Cedric Boissiere, Christian Serre and Leila Aparecida Chiavacci

Int. J. Mol. Sci. 2022, 23(14), 7670; https://doi.org/10.3390/ijms23147670 - 12 Jul 2022

Cited by 3 | Viewed by 2463

Abstract

Nanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment. Full article

(This article belongs to the Special Issue Nanomaterials for Theranostics and Tissue Engineering Applications)

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16 pages, 20848 KiB

Open AccessArticle

Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

by Dmitry V. Korolev, Galina A. Shulmeyster, Natalia V. Evreinova, Maria S. Syrovatkina, Maria S. Istomina, Victor N. Postnov, Ilia V. Aleksandrov, Aleksandr S. Krasichkov and Michael M. Galagudza

Int. J. Mol. Sci. 2022, 23(2), 932; https://doi.org/10.3390/ijms23020932 - 15 Jan 2022

Cited by 1 | Viewed by 1929

Abstract

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS₂/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals. Full article

(This article belongs to the Special Issue Nanomaterials for Theranostics and Tissue Engineering Applications)

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Review

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25 pages, 6725 KiB

Open AccessReview

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

by Elena G. Varlamova, Egor A. Turovsky and Ekaterina V. Blinova

Int. J. Mol. Sci. 2021, 22(19), 10808; https://doi.org/10.3390/ijms221910808 - 06 Oct 2021

Cited by 45 | Viewed by 4202

Abstract

This review presents the latest data on the importance of selenium nanoparticles in human health, their use in medicine, and the main known methods of their production by various methods. In recent years, a multifaceted study of nanoscale complexes in medicine, including selenium nanoparticles, has become very important in view of a number of positive features that make it possible to create new drugs based on them or significantly improve the properties of existing drugs. It is known that selenium is an essential trace element that is part of key antioxidant enzymes. In mammals, there are 25 selenoproteins, in which selenium is a key component of the active site. The important role of selenium in human health has been repeatedly proven by several hundred works in the past few decades; in recent years, the study of selenium nanocomplexes has become the focus of researchers. A large amount of accumulated data requires generalization and systematization in order to improve understanding of the key mechanisms and prospects for the use of selenium nanoparticles in medicine, which is the purpose of this review. Full article

(This article belongs to the Special Issue Nanomaterials for Theranostics and Tissue Engineering Applications)

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