Special Issue "Mesenchymal Stem Cells in Health and Disease"
Deadline for manuscript submissions: 31 October 2020.
Interests: Mesenchymal stem cells; T lymphocytes; flow cytometry; immunity; immunology of infectious diseases; immunomodulation; molecular immunology; inflammation
Mesenchymal stem cells (MSCs) are self-renewable, adult stem cells that reside in almost all postnatal tissue and organs, where they regulate homeostasis and promote the repair and regeneration of injured tissues. Damage-associated molecular patterns and alarmins, released from injured cells, induce the activation of MSCs, which, in turn, prevent the apoptosis of uninjured parenchymal cells and stimulate their survival and proliferation. MSCs suppress the effector functions of inflammatory neutrophils, monocytes, T lymphocytes, and natural killer (NK) and natural killer T (NKT) cells and promote the generation and expansion of immunosuppressive T regulatory cells (Tregs), leading to the alleviation of ongoing inflammation. Additionally, MSCs induce neoangiogenesis and promote the homing of alternatively activated macrophages and tolerogenic dendritic cells (DCs) to the inflamed tissues, where these immunoregulatory cells enhance the endogenous healing process.
MSC-derived extracellular vesicles (MSC-EVs) have shown beneficial therapeutic effects similar to those observed after the transplantation of their parental cells. MSC-EVs, distributed via biological fluids, can easily penetrate through the tissues and reach the target cells (even distant ones), enabling both paracrine and endocrine effects. MSC-EVs rapidly diffuse throughout the tissue, successfully delivering trophic and immunomodulatory factors that results in the attenuation of tissue injury and inflammation.
Therefore, due to their immunosuppressive and regenerative properties, MSCs and their EVs have been considered as potentially new therapeutic agents in the treatment of inflammatory and degenerative diseases.
This Special Issue calls for original research and review articles that may provide novel insights regarding the molecular and cellular mechanisms that are responsible for MSC-based effects and also current knowledge and future perspectives regarding the therapeutic application of MSCs and MSC-EVs in experimental and clinical settings.
Prof. Dr. Vladislav Volarevic
Manuscript Submission Information
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