Special Issue "Molecular Mechanisms of Periodontal Disease"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2020.
Interests: Periodontitis, Inflammation, Osteoclasts, Osteoblasts, Osteo-immunology, Commensal bacteria, Regenerative Medicien, Stem Cell biology, Mesenchymal stem cells, Neural Crest Cells, iPS cells, Organoids, Signal transduction
Periodontitis is a chronic inflammatory disease characterized by lymphocytic infiltration and alveolar bone destruction, along with tooth loss. Accumulated lines of evidence suggest that such destructive inflammation is elicited by host innate and adaptive immune response to periodontal biofilm-associated multiple microorganisms. In addition, several inflammatory cytokines produced from lymphocytes, leukocytes, fibroblasts, and gingival epithelial cells in the context of host immune responses were identified as key molecules inducing periodontal tissue destruction. More specifically, proinflammatory cytokines, including IL-6 and IL-17, facilitate the RNAKL expression level in fibroblasts or lymphocytes, which results in the induction of bone resorption. However, despite the advances in our understanding of its etiology, scientific endeavors to fight against periodontal disease stand still. Accordingly, it is required to deepen the understanding of a more detailed molecular mechanism of immune system against oral microorganisms to develop preventive or therapeutic regimens. To that end, this Special Issue focuses on novel immune reaction systems from the molecular level (microbe, microRNA, inflammatory cytokines signaling cascade, etc.) to the cellular level (Th1, Th2, Th17, Treg, and B cells activity, osteoclastogenesis, dendritic cells and monocytes immune response, the role of fibroblasts/epithelial cells in inflammation, etc.) in mouse periodontal disease models.
Assoc. Prof. Dr. Mikihito Kajiya
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- immune response
- periodontal pathogens
- bone resorption
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Butyrate decreases ICAM-1 expression in human oral epithelial cells
Authors: Reinhard Gruber
Title: Omega 3 Fatty Acids and apical periodontitis
Authors: Toshihisa Kawai