Special Issue "Commemorative Issue in Honor of Professor Uwe Heinemann: Metabolic Epilepsies"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2017) | Viewed by 52255
Interests: mitochondrial epilepsy; brain energy metabolism; neuroprotection; mitochondrial DNA maintenance; mitochondrial diseases; epilepsy genetics
This Special Issue is dedicated to Professor Uwe Heinemann on the occasion of his unexpected passing.
Epilepsy is a very common, severe and disabling neurological disorder with a major disease burden worldwide. Although the seizures can be well controlled by available medications in about two thirds of patients, the development of novel treatment strategies for the remaining third is largely hampered by our poor understanding of the underlying mechanisms. According to the classical view, seizures are the result of an imbalance between excitatory and inhibitory neuronal activities. Classical epilepsy research has been therefore focused on changes of synaptic transmission caused by altered ion channels and neurotransmitter receptors. Due to recent dramatic progress in uncovering the genetic cause of disease conditions associated with epilepsy, there is an emerging body of evidence that epilepsy has to be considered in a much broader context. Particularly, metabolic causes of seizures obtained recent attention.
This Special Issue, “Metabolic Epilepsies”, will cover a selection of recent research topics and current review articles about the contribution of alterations of brain metabolism to seizure activity. We are particularly interested in articles describing: (i) genetic findings in epilepsy not primary related to ion channels and neurotransmitter receptors; (ii) new concepts explaining seizure generation by metabolic alterations; and (iii) the use of new strategies for treatment and neuroprotection in metabolic epilepsies.
Professor Uwe Heinemann is one of the most outstanding and influential scientist in the field of epilepsy research who passed away on 8 September, 2016. He studied medicine at the Ludwig-Maximilians-University, Munich, followed by his doctoral studies and dissertation in Experimental Psychology, Oxford (1968–1971). His first postdoc at the Max Planck Institute for Psychiatry (1971–1981) and his Heisenberg fellowship (1981–1986) paved the way first to his professorship at University of Cologne (1986–1993) and then at the Charité-Medical University of Berlin (1993–2012), where he became the head of the Institute for Neurophysiology and later also the co-director of the NeuroCure Cluster of Excellence. Since 1999 he was the chairman of the Neuroscience Research Center of the Charité, where he continued to work as professor emeritus after his retirement in 2012 until his sudden death. Professor Uwe Heinemann was a member of numerous commissions and governing bodies, from within which he has given numerous impulses that have shaped the field of epilepsy research. These included the Commission on Neurobiology and Epilepsy and the Long Term Planning Commission of the International League Against Epilepsy, Advisory Board for the European Academy of Epilepsy, European Epilepsy Congress, European Neuroscience Conference and the Biannual Congress of the ILAE. He was past president of the German Epilepsy Society (1993–1995), and honorary member of the society since 2012. He was also one of the initiators of the Workshop on Neurobiology of the Epilepsies, which has gone on to become one of the most influential think tanks in epilepsy research today. His scientific excellence and integrative personality has been internationally recognized with numerous awards, including the international Michael Prize for Epilepsy Research (1977 and 1987), the Alfred Hauptmann Prize (1988), the Ambassador for Epilepsy Award (1989), the Basic Science AES Award (1992), and the European Epilepsy Award (2008).
Prof. Wolfram S. Kunz
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- Metabolic epilepsy
- Brain metabolism
- Epilepsy genetics
- Treatment of metabolic epilepsy