Next Article in Journal
Protein-Protein Interactions Prediction Using a Novel Local Conjoint Triad Descriptor of Amino Acid Sequences
Next Article in Special Issue
Metabolic Epilepsies—Commemorative Issue in Honor of Professor Uwe Heinemann
Previous Article in Journal
ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance
Previous Article in Special Issue
Hungry Neurons: Metabolic Insights on Seizure Dynamics
Open AccessReview

Metabolic Dysfunction and Oxidative Stress in Epilepsy

Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(11), 2365; https://doi.org/10.3390/ijms18112365
Received: 27 September 2017 / Revised: 27 October 2017 / Accepted: 30 October 2017 / Published: 8 November 2017
The epilepsies are a heterogeneous group of disorders characterized by the propensity to experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the underlying mechanisms of seizure initiation, seizure propagation, and comorbid conditions are incompletely understood. Metabolic changes including the production of reactive species are known to result from prolonged seizures and may also contribute to epilepsy development. In this review, we focus on the evidence that metabolic and redox disruption is both cause and consequence of epileptic seizures. Additionally, we discuss the promise of targeting redox processes as a therapeutic option in epilepsy. View Full-Text
Keywords: mitochondria; reactive oxygen species; seizures mitochondria; reactive oxygen species; seizures
Show Figures

Graphical abstract

MDPI and ACS Style

Pearson-Smith, J.N.; Patel, M. Metabolic Dysfunction and Oxidative Stress in Epilepsy. Int. J. Mol. Sci. 2017, 18, 2365.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop