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Special Issue "Lipid as a Cancer Therapeutic Target 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 December 2022 | Viewed by 2831

Special Issue Editors

Prof. Dr. Elisabetta Albi
E-Mail Website
Guest Editor
Department of Pharmaceutical Science, University of Perugia, 06100 Perugia, Italy
Interests: lipid metabolism; nuclear lipids; cancer; cell proliferation and differentiation; neurodegenerative disorders; liver; brain; thyroid
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrea Huwiler
E-Mail Website
Co-Guest Editor
Institute of Pharmacology, University of Bern, Inselspital, CH-3010 Bern, Switzerland
Interests: sphingolipid signaling; prostaglandins; chronic inflammatory kidney diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issue “Lipid as a Cancer Therapeutic Target

Lipids are not only components of cellular membranes but also constitute important signaling molecules. They can influence cellular signaling pathways via binding to extracellular cellular receptors or intracellular molecules, such as phosphatases and kinases. Additionally, they can form special membrane domains, which represent important signaling platforms for the activation of membrane-associated proteins. With regard to these multiple cellular functions, lipids are important players in physiological and pathophysiological processes and interesting targets for mostly incurable diseases such as cancer. Prostaglandin E2 (PGE2) and sphingosine-1 phosphate (S1P) are well-known lipids that promote cancer growth. However, other lipids are also deregulated in cancer, and interfering with the synthesis or binding of these lipids is a promising approach for cancer therapy.

This Special Issue will summarize the current knowledge of therapeutics that target lipids as a new treatment option for cancer therapy. We invite researchers in the broad field of sphingolipids, cholesterol, prostaglandins, leukotrienes, and phospholipids to contribute to this Special Issue.

Prof. Dr. Elisabetta Albi
Guest Editor
Prof. Dr. Andrea Huwiler
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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Article
Multifunctional Role of Lipids in Modulating the Tumorigenic Properties of 4T1 Breast Cancer Cells
Int. J. Mol. Sci. 2022, 23(8), 4240; https://doi.org/10.3390/ijms23084240 - 11 Apr 2022
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Abstract
Tumor growth and progression are linked to an altered lipid metabolism in the tumor microenvironment (TME), including tumor cells and tumor-associated macrophages (TAMs). A growing number of lipid metabolism targeting drugs have shown efficacy in anti-tumor therapy. In addition, exogenously applied lipids and [...] Read more.
Tumor growth and progression are linked to an altered lipid metabolism in the tumor microenvironment (TME), including tumor cells and tumor-associated macrophages (TAMs). A growing number of lipid metabolism targeting drugs have shown efficacy in anti-tumor therapy. In addition, exogenously applied lipids and lipid analogues have demonstrated anti-tumor activities in several cancers, including breast cancer. In this study, we investigated the anti-tumor efficacies of the natural lipids palmitic acid (PA), sphingomyelin (SM), ceramide (Cer) and docosahexaenoic acid (DHA) on breast cancer cells. All tested lipids reduced the malignancy of breast cancer cells in vitro by impairing cell proliferation, migration and invasiveness. PA showed superior anti-tumor properties, as it additionally impaired cancer cell viability by inducing apoptosis, without affecting healthy cells. Co-culture experiments further demonstrated that Cer and PA reduced the immunosuppressive phenotype of M2 macrophages and the M2 macrophage-promoted the epithelial–mesenchymal transition (EMT) and migration of breast cancer cells. At the molecular level, this coincided with the up-regulation of E-cadherin. Our results highlight a powerful role for exogenously applied PA and Cer in reducing breast cancer tumorigenicity by simultaneously targeting cancer cells and M2 macrophages. Our findings support the notion that lipids represent alternative biocompatible therapeutic agents for breast cancer. Full article
(This article belongs to the Special Issue Lipid as a Cancer Therapeutic Target 2.0)
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Article
A UHPLC-Mass Spectrometry View of Human Melanocytic Cells Uncovers Potential Lipid Biomarkers of Melanoma
Int. J. Mol. Sci. 2021, 22(21), 12061; https://doi.org/10.3390/ijms222112061 - 08 Nov 2021
Viewed by 825
Abstract
Melanoma is the deadliest form of skin cancer due to its ability to colonize distant sites and initiate metastasis. Although these processes largely depend on the lipid-based cell membrane scaffold, our understanding of the melanoma lipid phenotype lags behind most other aspects of [...] Read more.
Melanoma is the deadliest form of skin cancer due to its ability to colonize distant sites and initiate metastasis. Although these processes largely depend on the lipid-based cell membrane scaffold, our understanding of the melanoma lipid phenotype lags behind most other aspects of this tumor cell. Here, we examined a panel of normal human epidermal and nevus melanocytes and primary and metastatic melanoma cell lines to determine whether distinctive cell-intrinsic lipidomes can discern non-neoplastic from neoplastic melanocytes and define their metastatic potential. Lipidome profiles were obtained by UHPLC-ESI mass-spectrometry, and differences in the signatures were analyzed by multivariate statistical analyses. Significant and highly specific changes in more than 30 lipid species were annotated in the initiation of melanoma, whereas less numerous changes were associated with melanoma progression and the non-malignant transformation of nevus melanocytes. Notably, the “malignancy lipid signature” features marked drops in pivotal membrane lipids, like sphingomyelins, and aberrant elevation of ether-type lipids and phosphatidylglycerol and phosphatidylinositol variants, suggesting a previously undefined remodeling of sphingolipid and glycerophospholipid metabolism. Besides broadening the molecular definition of this neoplasm, the different lipid profiles identified may help improve the clinical diagnosis/prognosis and facilitate therapeutic interventions for cutaneous melanoma. Full article
(This article belongs to the Special Issue Lipid as a Cancer Therapeutic Target 2.0)
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Review

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Review
Hypercholesterolemia in Cancer and in Anorexia Nervosa: A Hypothesis for a Crosstalk
Int. J. Mol. Sci. 2022, 23(13), 7466; https://doi.org/10.3390/ijms23137466 - 05 Jul 2022
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Abstract
The relationship between cholesterol and cancer has been widely demonstrated. Clinical studies have shown changes in blood cholesterol levels in cancer patients. In parallel, basic research studies have shown that cholesterol is involved in the mechanisms of onset and progression of the disease. [...] Read more.
The relationship between cholesterol and cancer has been widely demonstrated. Clinical studies have shown changes in blood cholesterol levels in cancer patients. In parallel, basic research studies have shown that cholesterol is involved in the mechanisms of onset and progression of the disease. On the other hand, anorexic patients have high cholesterol levels and a high susceptibility to cancer. In this review, we first present a brief background on the relations among nutrition, eating disorders and cancer. Using several notable examples, we then illustrate the changes in cholesterol in cancer and in anorexia nervosa, providing evidence for their important relationship. Finally, we show a new possible link between cholesterol disorder in cancer and in anorexia nervosa. Full article
(This article belongs to the Special Issue Lipid as a Cancer Therapeutic Target 2.0)
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