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Lipids and Vitamins in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 1332

Special Issue Editors


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Guest Editor
Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
Interests: nutrition

Special Issue Information

Dear Colleagues,

Lipids and vitamins have significant influence in health and diseases. A lipid is any of various organic compounds that are insoluble in water. They include fats, waxes, oils, hormones, and certain components of membranes and function as energy-storage molecules and chemical messengers. The most important biological properties of lipids are their influence on cell permeability and the activity of many enzymes, participation in the transmission of a nerve impulse, muscle contraction, the formation of intercellular contacts, and in immunochemical processes. Vitamins are organic molecules (or a set of closely related molecules called vitamers) that are essential to an organism in small quantities for proper metabolic function. Essential nutrients cannot be synthesized in the organism in sufficient quantities for survival, and therefore must be obtained through the diet. In this project, we will explore the molecular mechanisms of how lipids and vitamins influence human’s health and diseases. Basic research studies and/or clinical studies accompanied by experimental data will be considered.

Prof. Dr. Elisabetta Albi
Dr. Paola Signorelli
Guest Editors

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Keywords

  • lipid
  • vitamin
  • metabolism
  • diet
  • nutrition

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Published Papers (1 paper)

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Review

19 pages, 864 KB  
Review
The Role of Vitamin C in Selected Autoimmune and Immune-Mediated Diseases: Exploring Potential Therapeutic Benefits
by Martyna Mochol, Lukasz Jablonowski, Andrzej Pawlik, Joanna Rasławska-Socha, Agnieszka Chamarczuk, Mariusz Lipski and Małgorzata Mazurek-Mochol
Int. J. Mol. Sci. 2025, 26(19), 9375; https://doi.org/10.3390/ijms26199375 - 25 Sep 2025
Viewed by 772
Abstract
Autoimmune diseases are characterized by immune response dysregulation against self-components, leading to chronic inflammation and tissue damage. Vitamin C (VitC), a water-soluble vitamin with established functions in antioxidant defence and collagen synthesis, has also been of interest based on its potential immunomodulatory effects. [...] Read more.
Autoimmune diseases are characterized by immune response dysregulation against self-components, leading to chronic inflammation and tissue damage. Vitamin C (VitC), a water-soluble vitamin with established functions in antioxidant defence and collagen synthesis, has also been of interest based on its potential immunomodulatory effects. This review discusses the role of VitC in the course and progression of (A) autoimmune diseases (multiple sclerosis, rheumatoid arthritis, Sjögren’s disease, type 1 diabetes, Hashimoto’s thyroiditis, pernicious anaemia, antiphospholipid syndrome), (B) other immune-mediated diseases (Crohn’s disease, periodontitis), and (C) Alzheimer’s disease, a neurodegenerative disorder with autoimmune features. Results from clinical, observational, and experimental trials show that VitC deficiency is common in many of these diseases and may contribute to increased oxidative stress and immune disequilibrium. Supplementation has been associated with improved antioxidant levels, control of inflammatory mediators, and, in some cases, clinical outcomes like disease activity decrease or symptom load. Although findings vary across conditions and few large, randomized trials are available, the overall evidence indicates that maintaining good VitC status can be useful in maintaining immune homeostasis and reducing inflammation. VitC should be viewed as an adjunct to be employed safely, perhaps and ideally within larger treatment regimens, but not in place of effective therapies. Further research, including large-scale clinical trials, will be required to determine more clearly optimal dosing, timing of treatment, and patient population most likely to benefit. By integration of current knowledge, this review recognizes both promise in VitC for treatment of autoimmune/immune-mediated disease and promise in its potential use within future treatment regimens. Full article
(This article belongs to the Special Issue Lipids and Vitamins in Health and Disease)
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