Special Issue "Natural Inhibitors of Amyloid Aggregation"
Deadline for manuscript submissions: closed (20 December 2019).
Interests: polyglutamine proteins; amyloid diseases; antiamyloid compounds; nanobiotechnology; Caenorhabditis elegans
Interests: dementia; Alzheimer’s disease; Parkinson’s disease; neurodegeneration; protein aggregation; molecular chaperones; antibodies; protein therapeutics; protein design; biophysiscs
The formation of fibrillar aggregates, called amyloids, of normally soluble proteins in the nervous system is a pathological event strongly linked with selective neuronal death. This mechanism underlies the onset and progression of several forms of dementia and motor neuron diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.
Amyloid aggregation is an extremely intricate process that involves several events and the formation of transient and highly toxic species, called oligomers. The intrinsic instability of oligomers represents a major challenge in the field, which has hindered the development of therapeutic strategies. Nevertheless, as a result of several recent advances, current drug discovery approches aimed at inhibiting amyloid aggregation and, specifically, the formation of oligomers are under development and show promising results. Many of these are based on the use of natural compounds such as metabolites and phenols, and also proteins such as antibodies and chaperones.
This Special Issue will cover updated research on the natural inhibitors of neurodegenerative amyloid aggregation, such as small molecules and antibodies. Its scope is multidisciplinary, hosting contributions based on biochemical, biophysical and computational approaches. It will encompass experimentations performed in vitro as well as in cellular and animal models, including those aimed at manipulating the protein homeostasis system.
Prof. Dr. Paolo Tortora
Dr. Francesco A. Aprile
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Protein aggregation
- Small molecules
- Protein therapeutics