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Special Issue "Inhalation Toxicology and Biological Response"
Deadline for manuscript submissions: 31 January 2020.
In the last decades, significant steps forward have been realized in the characterization of the mode of action of particulate matter (PM). Despite the information available on the toxicological effects of fine PM (PM2.5) on lung epithelial cells, there is still a significant lack of information on the effects of PM2.5 and ultrafine PM (UFP) on different tissues, first of all brain cells, and/or on exposing the in vitro models at the air liquid interface (ALI, micro cell cultures). In addition, growing interest is devoted to understanding the effects of PM and the UFP emitted by specific sources (such as diesel engines and biomass burning). Finally, interest in understanding the potential toxicological effects of indoor air pollution is gaining scientific attention in relation to the significant concentration of fine PM; UFP; and volatile organic compounds generated by specific sources, some of which include, for example, e-cigarettes and vaping cigarettes.
Papers submitted to this Special Issue must report high novelty results on the potential biological effects of PM and UFP. The identification of the molecular pathways activated by these particulates on cells that are representative of relevant target tissues is a reference topic. In addition, the application of innovative exposure systems; the use of 3D in vitro models; and the analysis of epigenetic modifications, metabolomics, and proteomics effects are also of interest, with a special emphasis on the modification, which may shed light on the mode of action of the effects fine and ultrafine particle on human health.
Dr. Maurizio Gualtieri
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Indoor and outdoor air pollution
- Air liquid interface exposure
- Combustion processes emission: biomass burning, vehicles emission, e-cigarette smoke, and indoor sources
- Fine and ultrafine particulate matter
- Oxidative stress
- DNA damages
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Deciphering the Code between Environment and Disease: The Effect of Particulate Matter on Cancer Hallmarks
Abstract: Air pollution has been recognized as global health problem, causing around 7 million deaths worldwide and representing one of the highest environmental crises that we are facing now. Near to 30% of new lung cancer cases are associated to air pollution, and the impact is more evident in major cities. In this review, we summarize and discuss the evidences regarding the effect of particulate matter and its impact in carcinogenesis, considering the “hallmarks of cancer” described by Hanahan and Weinberg as a guide to describe the findings that supports the impact of particulate matter during cancer development.
Keywords: Air pollution; particulate matter; cancer hallmarks