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Special Issue "Health Benefits of Resveratrol 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 January 2020).

Special Issue Editor

Dr. Giulia Malaguarnera
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Guest Editor
Research Center “The Great Senescence”, University of Catania, 95100 Catania, Italy
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Resveratrol (RV) is a natural phenol found in red grapes, mulberries, peanuts, wines and tea, and can be extracted from red wine during fermentation of grape skin. The mechanism by which RV exerts favorable effects is related to induction of genes for oxidative phosphorylation and mitochondrial biogenesis. It has been reported that RV plays a role as an antinflammatory, antioxidant, antiviral, and exerts anticancer activities through many different mechanisms. Patients with higher anxiety traits, depression, and fatigue showed a distinct metabolic profile, indicative of a different energy homeostasis, hormonal metabolism and gut microbial activity. The daily consumption of RV resulted in a significant modification in the microbial metabolism, with potential long-term health consequences. A human intervention study indicated that consumption of RV increased the number of Enterococcus, Prevotella, and Bacterioides uniformis. Several beneficial effects have been observed in human beings, but others studies are mandatory to continue with the scientific research in this field. Indeed, new knowledge concerning the “Health Benefits of Resveratrol” could enable the development of novel functional foods or nutraceuticals, incorporating resveratrol, suitable for preventing or treating diseases, such as cancer, cardiovascular diseases, obesity, dislipemia, insulin resistance and diabetes, liver diseases, and other disorders.

Dr. Giulia Malaguarnera
Guest Editor

Manuscript Submission Information

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Keywords

  • Resveratrol supplementation
  • Resveratrol metabolites
  • Sirtuins
  • Aging
  • Epigenetic
  • Benefits in chronic disease
  • Treatment

Published Papers (1 paper)

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Research

Open AccessArticle
Effects of Orally Administered Resveratrol on TNF, IL-1β, Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study
Int. J. Mol. Sci. 2020, 21(4), 1453; https://doi.org/10.3390/ijms21041453 - 20 Feb 2020
Abstract
Resveratrol, a phytophenol, is a commonly used equine nutraceutical supplement touted to exert anti-inflammatory effects. The effect of orally administered resveratrol on tumor necrosis factor (TNF), interleukin-1β (IL-1β), leukocyte phagocytic activity or oxidative burst function have not been reported in horses. The objective [...] Read more.
Resveratrol, a phytophenol, is a commonly used equine nutraceutical supplement touted to exert anti-inflammatory effects. The effect of orally administered resveratrol on tumor necrosis factor (TNF), interleukin-1β (IL-1β), leukocyte phagocytic activity or oxidative burst function have not been reported in horses. The objective of this study was to determine the effects of a commercially available, orally administered resveratrol product on innate immune functions in healthy adult horses. Whole blood was collected from 12 horses prior to and following 3 weeks of treatment with either the manufacturer’s recommended dose of resveratrol or placebo. Phagocytosis, oxidative burst and pathogen associated molecular pattern (PAMP) motif-stimulated leukocyte production of TNF and IL-1β were compared pre- and post-treatment between treatment groups. Phagocytosis and oxidative burst capacity were evaluated via flow cytometry. Tumor necrosis factor and IL-1β were measured using cytotoxicity and ELISA assays, respectively. There were no significant differences in phagocytosis, oxidative burst or stimulated TNF or IL-1β production between resveratrol and placebo treatment groups. Orally administered resveratrol at a routinely recommended dose for a duration of 3 weeks did not significantly affect phagocytic activity, oxidative burst function or PAMP-stimulated leukocyte cytokine production. Full article
(This article belongs to the Special Issue Health Benefits of Resveratrol 2.0)
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