International Journal of Molecular Sciences

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Dr. Agustin F. Fernandez

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Guest Editor

1. Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), Avda. de Roma, s/n., Oviedo, Spain
2. Laboratorio de Epigenética del Cáncer y Nanomedicina, Ed. FINBA Planta 0, 33011 Oviedo, Spain
Interests: epigenetics; epigenomics; aging; cancer; environmental epigenetics; nanomedicine; nanomaterials; rare diseases
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Dr. Rocio G. Urdinguio

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Guest Editor

1. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Institute of Oncology of Asturias (IUOPA), Avda. de Roma, s/n., Oviedo, Spain
2. Laboratorio de Epigenética del Cáncer y Nanomedicina, Ed. FINBA Planta 0, 33011 Oviedo, Spain
Interests: epigenetics; epigenomics; aging; cancer; environmental epigenetics; nanomedicine; nanomaterials; rare diseases

Special Issue Information

Dear Colleagues,

This Special Issue is focused on understanding the role of epigenetic mechanisms in cancer development and progression by examining the entire epigenome. This involves investigating various epigenetic markers, including DNA methylation, histone post-translational markers, and other molecular markers and mechanisms such as non-coding RNAs and the chromatin 3D structure. Furthermore, we aim to explore the functional consequences of changes in epigenetic markers by integrating data from other omics layers, such as transcriptomics, proteomics, and metabolomics.

Dr. Agustin F. Fernandez
Dr. Rocio G. Urdinguio
Guest Editors

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Keywords

epigenomics
DNA methylation
histone post-translational markers
non-coding RNAs
3D chromatin structure
cancer

Published Papers (1 paper)

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96 pages, 2846 KiB

Open AccessReview

Super-Enhancers and Their Parts: From Prediction Efforts to Pathognomonic Status

by Anastasia V. Vasileva, Marina G. Gladkova, German A. Ashniev, Ekaterina D. Osintseva, Alexey V. Orlov, Ekaterina V. Kravchuk, Anna V. Boldyreva, Alexander G. Burenin, Petr I. Nikitin and Natalia N. Orlova

Int. J. Mol. Sci. 2024, 25(6), 3103; https://doi.org/10.3390/ijms25063103 - 07 Mar 2024

Viewed by 1252

Abstract

Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene expression by promoting large-scale transcriptional responses in various cell types and tissues. Recent research suggests that alterations in super-enhancer activity can contribute to the development and progression of various disorders. The aim of this research is to explore the multifaceted roles of super-enhancers in gene regulation and their significant implications for understanding and treating complex diseases. Here, we study and summarise the classification of super-enhancer constituents, their possible modes of interaction, and cross-regulation, including super-enhancer RNAs (seRNAs). We try to investigate the opportunity of SE dynamics prediction based on the hierarchy of enhancer single elements (enhancers) and their aggregated action. To further our understanding, we conducted an in silico experiment to compare and differentiate between super-enhancers and locus-control regions (LCRs), shedding light on the enigmatic relationship between LCRs and SEs within the human genome. Particular attention is paid to the classification of specific mechanisms and their diversity, exemplified by various oncological, cardiovascular, and immunological diseases, as well as an overview of several anti-SE therapies. Overall, the work presents a comprehensive analysis of super-enhancers across different diseases, aiming to provide insights into their regulatory roles and may act as a rationale for future clinical interventions targeting these regulatory elements. Full article

(This article belongs to the Special Issue Epigenomics in Cancer Research: A Comprehensive Approach)

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Epigenomics in Cancer Research: A Comprehensive Approach

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