Special Issue "Drug Hypersensitivity"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2017)
Prof. Dr. Werner J. P Pichler
The old immunological dogma that small molecules do not interfere with the specific immune system was recently challenged by studying patients with drug hypersensitivity reactions: Drugs were found to be able to directly bind to immune receptors like HLA or TCR and thus lead to immune activations (pharmacological interaction with immune receptors, p-i concept). This finding was surprising as it opened a new area of basic immunology, namely how small molecules interact with the immune system; and it demonstrated once again that an in depth study of an acquired, human disease can also contribute to our understanding of basic scientific principles.
In this Special Issue of IJMS, a collection of papers will address the various mechanism of drug hypersensitivity: By linking molecular and clinical research of drug hypersensitivity, the role of small molecules in specific immunity in general may be better clarified. This should have an impact on incidence and severity and prediction of drug hypersensitivity reactions and may also help to understand other, environmental or man-made diseases.
Prof. Dr. Werner J. Pichler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- p-i concept
- basophil activation test
- T cell stimulation