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Int. J. Mol. Sci. 2017, 18(6), 1222;

The Value of In Vitro Tests to Diminish Drug Challenges

Research Laboratory-Allergy Unit, Biomedical Institute of Málaga-IBIMA, Regional University Hospital of Malaga-UMA, Málaga 29009, Spain
Allergy Service, IBIMA-Regional University Hospital of Malaga-UMA, Málaga 29009, Spain
Department of Organic Chemistry, University of Málaga, Biomedical Institute of Málaga-IBIMA, Málaga 29071, Spain
Andalusian Center for Nanomedicine and Biotechnology-BIONAND, Málaga 29590, Spain
Author to whom correspondence should be addressed.
Academic Editor: Werner J. P. Pichler
Received: 4 May 2017 / Revised: 31 May 2017 / Accepted: 2 June 2017 / Published: 7 June 2017
(This article belongs to the Special Issue Drug Hypersensitivity)
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Drug hypersensitivity reactions have multiple implications for patient safety and health system costs, thus it is important to perform an accurate diagnosis. The diagnostic procedure includes a detailed clinical history, often unreliable; followed by skin tests, sometimes with low sensitivity or unavailable; and drug provocation testing, which is not risk-free for the patient, especially in severe reactions. In vitro tests could help to identify correctly the responsible agent, thus improving the diagnosis of these reactions, helping the physician to find safe alternatives, and reducing the need to perform drug provocation testing. However, it is necessary to confirm the sensitivity, specificity, negative and positive predictive values for these in vitro tests to enable their implementation in clinical practice. In this review, we have analyzed these parameters from different studies that have used in vitro test for evaluating drug hypersensitivity reactions and estimated the added value of these tests to the in vivo diagnosis. View Full-Text
Keywords: drug; hypersensitivity; allergy; diagnosis; in vitro; IgE; T-cells; basophils; cytokines; immunoassays drug; hypersensitivity; allergy; diagnosis; in vitro; IgE; T-cells; basophils; cytokines; immunoassays

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Mayorga, C.; Doña, I.; Perez-Inestrosa, E.; Fernández, T.D.; Torres, M.J. The Value of In Vitro Tests to Diminish Drug Challenges. Int. J. Mol. Sci. 2017, 18, 1222.

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