Special Issue "Copper in Biology: Maturation of Copper Proteins and Copper Homeostasis"
Deadline for manuscript submissions: closed (20 June 2019).
Interests: structural biology; solution NMR; protein structure determination by NMR; protein-small molecules interaction; protein-protein interaction; metalloproteins; metal homeostasis
Special Issues and Collections in MDPI journals
Copper is an essential transition metal ion found in many key human enzymes. Its ability to assume distinct redox states by cycling between oxidized copper(II) and reduced copper(I) makes copper an appropriate cofactor in proteins, showing a wide range of catalytic functions, such as reactive oxygen species detoxification, electron transfer and mitochondrial functions. Copper redox properties can also lead to cellular oxidative damage when it is found in excess concentrations. Copper can participate in reactions that lead to the production of highly-reactive oxidative species, which cause DNA damage and oxidation of proteins and lipids. Moreover, the ability of copper to bind at sites of other metal ions can have devastating effects for various cellular functions. In order to prevent the binding of the “wrong” copper ion, cells have developed very efficient homeostatic and trafficking mechanisms. Thus, copper distribution, exploitation and excretion is tightly regulated in cells. Molecular recognition by protein–protein interactions efficiently guarantees the correct delivery of copper to Cu-dependent enzymes.
This Special Issue, "Copper in Biology: Maturation of Copper Proteins and Copper Homeostasis", will be comprised of original research papers and reviews covering various aspects of the field. An overview on copper proteins will be considered, and original papers aim to unravel the precise molecular nature of copper within different cellular compartments are welcome. Contributions that show recent advances in maturation of copper proteins and copper homeostasis processes will be also considered.
Dr. Francesca Cantini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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