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Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus

1
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA
2
Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel
3
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 1980; https://doi.org/10.3390/ijms20081980
Received: 18 March 2019 / Revised: 16 April 2019 / Accepted: 17 April 2019 / Published: 23 April 2019
Copper is an essential micronutrient for the opportunistic human pathogen, Aspergillus fumigatus. Maintaining copper homeostasis is critical for survival and pathogenesis. Copper-responsive transcription factors, AceA and MacA, coordinate a complex network responsible for responding to copper in the environment and determining which response is necessary to maintain homeostasis. For example, A. fumigatus uses copper exporters to mitigate the toxic effects of copper while simultaneously encoding copper importers and small molecules to ensure proper supply of the metal for copper-dependent processes such a nitrogen acquisition and respiration. Small molecules called isocyanides recently found to be produced by A. fumigatus may bind copper and partake in copper homeostasis similarly to isocyanide copper chelators in bacteria. Considering that the host uses copper as a microbial toxin and copper availability fluctuates in various environmental niches, understanding how A. fumigatus maintains copper homeostasis will give insights into mechanisms that facilitate the development of invasive aspergillosis and its survival in nature. View Full-Text
Keywords: copper homeostasis; Aspergillus fumigatus; secondary metabolites copper homeostasis; Aspergillus fumigatus; secondary metabolites
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MDPI and ACS Style

Raffa, N.; Osherov, N.; Keller, N.P. Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus. Int. J. Mol. Sci. 2019, 20, 1980. https://doi.org/10.3390/ijms20081980

AMA Style

Raffa N, Osherov N, Keller NP. Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus. International Journal of Molecular Sciences. 2019; 20(8):1980. https://doi.org/10.3390/ijms20081980

Chicago/Turabian Style

Raffa, Nicholas; Osherov, Nir; Keller, Nancy P. 2019. "Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus" Int. J. Mol. Sci. 20, no. 8: 1980. https://doi.org/10.3390/ijms20081980

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