Special Issue "Advances on Chelation in Medicine"
Deadline for manuscript submissions: 30 June 2020.
Interests: drug design development and clinical use; orphan drugs; orphan diseases; drug risk/benefit assessment; drug targeting; drug clinical protocol design; drug interactions; chelation therapies; metal complex therapies; antioxidant therapies; ADMET properties
Special Issues and Collections in MDPI journals
This Special Issue aims to present the current state of knowledge and new developments in the clinical use, application and effects of chelating drugs. Many areas are covered, including the use of chelating drugs for metal detoxification, as antioxidants, anticancer and anti-infective agents, and as modulators of protein function or pathways associated with disease. In addition, we will cover the use of chelator–metal complexes for increasing essential metal absorption; in clinical diagnosis, e.g., Tc and Gd complexes; as anticancer agents, e.g., Pt, Cu and Ga complexes. Important areas also include recent advances on the molecular, pharmacological, toxicological and other properties of chelating drugs, as well as new mechanisms of action, posology and interactions with other drugs. Such information is pivotal for designing therapeutic strategies for the effective treatment of millions of patients with many diseases such as thalassaemia, cancer and neurodegenerative diseases. It is envisaged that chelation in multifactorial diseases can play a major role and be used as a main, alternative or adjuvant therapy. In this context, improved therapeutic strategies could be developed and adopted based on combination therapies, target-specific and prodrug design methods and other aspects that can fulfil personalised medicine characteristics.
Prof. George J. Kontoghiorghes
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- chelation therapy
- metal detoxification
- chelator antioxidants
- chelator–metal complex applications
- chelating drug effects
- maltol iron treatments
- iron overload treatment
- thalassaemia treatment
- iron deficiency treatment
- iron metabolic disorders treatment
- copper overload treatment
- heavy metal detoxification
- cancer treatment
- neurodegenerative disease treatment
- tissue damage treatment
- kidney disease treatment
- ischaemia/reperfusion injury treatment
- antimicrobial treatments
- mitochondrial disease treatment
- ageing treatment
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Current biomedical use of copper chelation threrapy
Authors: Gabriele Toietta; et al.
Title: EDTA chelation therapy in the treatment of neurodegenerative diseases: an update
Authors: Maria Elena Ferrero; et al.
Title: Manipulating the in vivo behaviour of radiometals with chelators, from pretargeting to clearance agents
Authors: Cinzia Imberti; et al.
Title: Discovery of 3-hydroxyquinazoline-2,4(1H,3H)-dione Derivatives:
A Series of Metal Ions Chelators with Potent Anti-HCV Activities
Authors: Yang Cao; et al.