Special Issue "Cell Signaling in Neurodegeneration"
Deadline for manuscript submissions: closed (31 July 2020).
Interests: small GTPases; glycogen metabolism; PTMs; neurodegeneration and signaling pathways
Special Issues and Collections in MDPI journals
Cellular communication and signaling are keys to coordinate the functions of the different cell types that constitute organisms. These systems control processes such as inter- and intracellular transport, changes in cell morphology, energy consumption, and accumulation, cell differentiation, cell migration, cell proliferation or cell death. These controls are established through gene regulation and the function of small and macromolecules, such as proteins. It is estimated that more than 20% of the genes of the human genome encode proteins are involved in the signal transduction pathways that regulate changes in localization, trafficking, degradation, of molecules or functional intermolecular interactions. Understanding how cells receive and coordinate signals from the environment and/or other cells to finally emit a physiological response is the basis for correcting dysfunctionalities that cause unregulated modifications of these signaling systems and result in multiple pathologies, including neurodegenerative diseases.
The purpose of this Special Issue of IJMS is to explore this paradigm of cell signaling in neurodegeneration in order to understand the molecular mechanisms that lead to these neurodegenerative processes. Therefore, this Special Issue provides an excellent opportunity to cover studies and reports on cell cultures, animal models, revealing new knowledge about the underlying pathophysiology/pathogenesis, or new aspects that could affect positively the progressive development of efficient molecules to fight those neurodegenerative diseases effectively.
Prof. José L Zugaza
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- small GTPases
- Post-translational modification (PTM)
- enzyme activity
- gene expression
- epigenetic modifications